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• W2065932079 startingPage "1033" @default.
• W2065932079 abstract "The effect of somatostatin-14 (SST) and the SST analogues SMS and RC160 on human natural killer (NK) activity mediated by large granular lymphocytes (LGL), as well as on IL-2-and/or anti-CD16 monoclonal antibody (mAb)-induced activation of these cells, was investigated. The NK activity of LGL was studied by the release of 51 Cr by the erythroleukemia-derived cell line K562, whereas 51 Cr release by the P815 murine mastocytoma-derived cell line, for which lysis was redirected by the use of an anti-CD16 mAb, was used to study the cytolytic potential of these cells. IL-2 was used at the final concentration of 100 IU and was incubated overnight with LGL. SST and the analogues, added to these systems at final doses ranging from 10 −12 to 10 −5 M , were inhibitory of the NK cell activity to K562, with a dose-response curve starting from 10 −8 M and reaching a significant level at 10 −6 M . On the contrary, no effect was observed on the redirected killing assay to P815 and on the IL-2-induced activation of NK cells. These results provide additional evidence for the immunomodulatory action of somatostatin." @default.
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• W2065932079 date "1994-01-01" @default.
• W2065932079 modified "2023-09-27" @default.
• W2065932079 title "Inhibitory effect of somatostatin-14 and some analogues on human natural killer cell activity" @default.
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• W2065932079 doi "https://doi.org/10.1016/0196-9781(94)90067-1" @default.
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