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- W2065934473 abstract "Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AICD), leading to tolerance. AICD in B lymphocytes is a highly regulated event initiated by crosslinking of the B cell receptor (BCR). BCR engagement initiates several signaling events such as activation of PLCgamma, Ras, and PI3K, which generally speaking, lead to survival. However, in the absence of survival signals (CD40 or IL-4R engagement), BCR crosslinking can also promote apoptotic signal transduction pathways such as activation of effector caspases, expression of pro-apoptotic genes, and inhibition of pro-survival genes. The complex interplay between survival and death signals determines the B cell fate and, consequently, the immune response." @default.
- W2065934473 created "2016-06-24" @default.
- W2065934473 creator A5043389683 @default.
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- W2065934473 date "2000-09-01" @default.
- W2065934473 modified "2023-10-17" @default.
- W2065934473 title "Activation-induced cell death in B lymphocytes" @default.
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- W2065934473 doi "https://doi.org/10.1038/sj.cr.7290047" @default.
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