FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065948396> ?p ?o ?g. }

• W2065948396 endingPage "348" @default.
• W2065948396 startingPage "344" @default.
• W2065948396 abstract "Background Major depressive disorder (MDD) occurs in a subset of patients receiving interferon-alpha treatment, although many are resilient to this side effect. Genetic differences in the serotonin reuptake transporter promoter (5-HTTLPR) may interact with the inflammatory system and influence depression risk. Methods A cohort of 71 nondepressed hepatitis C patients about to receive interferon-alpha was prospectively followed, employing a diagnostic structured clinical interview (Structured Clinical Interview for DSM-IV Axis I Disorders [SCID-I]) and self-report questionnaires. Patients were genotyped for the 5-HTTLPR (LG, LA, and S) and the variable number of tandem repeats (VNTR) polymorphism in the second intron. Kaplan-Meier analyses were used to compare major depression incidence. Genotype effects on sleep quality (Pittsburgh Sleep Quality Index) and Beck Depression Inventory (BDI) were assessed using mixed-effect repeated-measure analyses. Results The LA allele was associated with a decreased rate of developing MDD (Mantel-Cox log rank test p < .05) with the LA/LA genotype being the most resilient. This genotype was also associated with better sleep quality [F(61.2,2) = 3.3, p < .05]. The ability of baseline sleep quality to predict depression incidence disappeared when also including genotype in the model. Conversely, the relationship of neuroticism with depression incidence (B = .07, SE = .02, p < .005) was not mitigated when including genotype. Conclusions Using a prospective design, 5-HTTLPR is associated with MDD incidence during interferon-alpha treatment. Preliminary evidence that this effect could be mediated by effects on sleep quality was observed. These findings provide support for a possible interaction between inflammatory cytokine (interferon-alpha) exposure and 5-HTTLPR variability in MDD. Major depressive disorder (MDD) occurs in a subset of patients receiving interferon-alpha treatment, although many are resilient to this side effect. Genetic differences in the serotonin reuptake transporter promoter (5-HTTLPR) may interact with the inflammatory system and influence depression risk. A cohort of 71 nondepressed hepatitis C patients about to receive interferon-alpha was prospectively followed, employing a diagnostic structured clinical interview (Structured Clinical Interview for DSM-IV Axis I Disorders [SCID-I]) and self-report questionnaires. Patients were genotyped for the 5-HTTLPR (LG, LA, and S) and the variable number of tandem repeats (VNTR) polymorphism in the second intron. Kaplan-Meier analyses were used to compare major depression incidence. Genotype effects on sleep quality (Pittsburgh Sleep Quality Index) and Beck Depression Inventory (BDI) were assessed using mixed-effect repeated-measure analyses. The LA allele was associated with a decreased rate of developing MDD (Mantel-Cox log rank test p < .05) with the LA/LA genotype being the most resilient. This genotype was also associated with better sleep quality [F(61.2,2) = 3.3, p < .05]. The ability of baseline sleep quality to predict depression incidence disappeared when also including genotype in the model. Conversely, the relationship of neuroticism with depression incidence (B = .07, SE = .02, p < .005) was not mitigated when including genotype. Using a prospective design, 5-HTTLPR is associated with MDD incidence during interferon-alpha treatment. Preliminary evidence that this effect could be mediated by effects on sleep quality was observed. These findings provide support for a possible interaction between inflammatory cytokine (interferon-alpha) exposure and 5-HTTLPR variability in MDD." @default.
• W2065948396 created "2016-06-24" @default.
• W2065948396 creator A5000921316 @default.
• W2065948396 creator A5016542452 @default.
• W2065948396 creator A5071539931 @default.
• W2065948396 creator A5086284606 @default.
• W2065948396 date "2009-02-01" @default.
• W2065948396 modified "2023-10-18" @default.
• W2065948396 title "Risk for Depression During Interferon-Alpha Treatment Is Affected by the Serotonin Transporter Polymorphism" @default.
• W2065948396 cites W116573120 @default.
• W2065948396 cites W130054925 @default.
• W2065948396 cites W1854131685 @default.
• W2065948396 cites W1969065116 @default.
• W2065948396 cites W1973770367 @default.
• W2065948396 cites W1974215244 @default.
• W2065948396 cites W1976730458 @default.
• W2065948396 cites W1979907943 @default.
• W2065948396 cites W1982050481 @default.
• W2065948396 cites W1984455353 @default.
• W2065948396 cites W1986730863 @default.
• W2065948396 cites W1997115145 @default.
• W2065948396 cites W1998439676 @default.
• W2065948396 cites W2002250647 @default.
• W2065948396 cites W2003982930 @default.
• W2065948396 cites W2010208774 @default.
• W2065948396 cites W2021594711 @default.
• W2065948396 cites W2038323449 @default.
• W2065948396 cites W2039956056 @default.
• W2065948396 cites W2048952961 @default.
• W2065948396 cites W2052969065 @default.
• W2065948396 cites W2057591165 @default.
• W2065948396 cites W2060345189 @default.
• W2065948396 cites W2062355463 @default.
• W2065948396 cites W2063139961 @default.
• W2065948396 cites W2068465151 @default.
• W2065948396 cites W2069799601 @default.
• W2065948396 cites W2082179080 @default.
• W2065948396 cites W2084419139 @default.
• W2065948396 cites W2090311753 @default.
• W2065948396 cites W2092395511 @default.
• W2065948396 cites W2109026965 @default.
• W2065948396 cites W2110909777 @default.
• W2065948396 cites W2114149118 @default.
• W2065948396 cites W2125401121 @default.
• W2065948396 cites W2137877753 @default.
• W2065948396 cites W2138970660 @default.
• W2065948396 cites W2145430042 @default.
• W2065948396 cites W2151135161 @default.
• W2065948396 cites W2151487996 @default.
• W2065948396 cites W2152432656 @default.
• W2065948396 cites W2154516720 @default.
• W2065948396 cites W2155574232 @default.
• W2065948396 cites W2156743186 @default.
• W2065948396 cites W2161085199 @default.
• W2065948396 cites W2162196924 @default.
• W2065948396 cites W2163709153 @default.
• W2065948396 cites W2168572474 @default.
• W2065948396 cites W4248629646 @default.
• W2065948396 cites W65867874 @default.
• W2065948396 doi "https://doi.org/10.1016/j.biopsych.2008.08.009" @default.
• W2065948396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2654233" @default.
• W2065948396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18801474" @default.
• W2065948396 hasPublicationYear "2009" @default.
• W2065948396 type Work @default.
• W2065948396 sameAs 2065948396 @default.
• W2065948396 citedByCount "125" @default.
• W2065948396 countsByYear W20659483962012 @default.
• W2065948396 countsByYear W20659483962013 @default.
• W2065948396 countsByYear W20659483962014 @default.
• W2065948396 countsByYear W20659483962015 @default.
• W2065948396 countsByYear W20659483962016 @default.
• W2065948396 countsByYear W20659483962017 @default.
• W2065948396 countsByYear W20659483962018 @default.
• W2065948396 countsByYear W20659483962020 @default.
• W2065948396 countsByYear W20659483962022 @default.
• W2065948396 countsByYear W20659483962023 @default.
• W2065948396 crossrefType "journal-article" @default.
• W2065948396 hasAuthorship W2065948396A5000921316 @default.
• W2065948396 hasAuthorship W2065948396A5016542452 @default.
• W2065948396 hasAuthorship W2065948396A5071539931 @default.
• W2065948396 hasAuthorship W2065948396A5086284606 @default.
• W2065948396 hasBestOaLocation W20659483962 @default.
• W2065948396 hasConcept C104317684 @default.
• W2065948396 hasConcept C118552586 @default.
• W2065948396 hasConcept C126322002 @default.
• W2065948396 hasConcept C135763542 @default.
• W2065948396 hasConcept C139719470 @default.
• W2065948396 hasConcept C15744967 @default.
• W2065948396 hasConcept C162324750 @default.
• W2065948396 hasConcept C170493617 @default.
• W2065948396 hasConcept C187288502 @default.
• W2065948396 hasConcept C203014093 @default.
• W2065948396 hasConcept C2775864247 @default.
• W2065948396 hasConcept C2776178377 @default.
• W2065948396 hasConcept C2776867660 @default.
• W2065948396 hasConcept C2778897192 @default.
• W2065948396 hasConcept C2779631380 @default.
• W2065948396 hasConcept C2780051608 @default.

• next