Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065962160> ?p ?o ?g. }
- W2065962160 endingPage "620" @default.
- W2065962160 startingPage "606" @default.
- W2065962160 abstract "Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine repeat expansion in huntingtin. A newly developed bacterial artificial chromosome transgenic mouse model (BACHD) reproduces phenotypic features of HD including predominantly neuropil-associated protein aggregation and progressive motor dysfunction with selective neurodegenerative pathology. Motor dysfunction has been shown to precede neuropathology in BACHD mice. We therefore investigated the progression of synaptic pathology in pyramidal cells and interneurons of the superficial motor cortex of BACHD mice. Whole-cell patch clamp recordings were performed on layer 2/3 primary motor cortical pyramidal cells and parvalbumin interneurons from BACHD mice at 3 months, when the mice begin to demonstrate mild motor dysfunction, and at 6 months, when the motor dysfunction is more severe. Changes in synaptic variances were detectable at 3 months, and at 6 months BACHD mice display progressive synaptic pathology in the form of reduced cortical excitation and loss of inhibition onto pyramidal cells. These results suggest that progressive alterations of the superficial cortical circuitry may contribute to the decline of motor function in BACHD mice. The synaptic pathology occurs prior to neuronal degeneration and may therefore prove useful as a target for future therapeutic design." @default.
- W2065962160 created "2016-06-24" @default.
- W2065962160 creator A5017700541 @default.
- W2065962160 creator A5052012618 @default.
- W2065962160 creator A5070864680 @default.
- W2065962160 creator A5075336895 @default.
- W2065962160 date "2008-12-01" @default.
- W2065962160 modified "2023-10-18" @default.
- W2065962160 title "Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease" @default.
- W2065962160 cites W1572968198 @default.
- W2065962160 cites W1605454745 @default.
- W2065962160 cites W1713405122 @default.
- W2065962160 cites W1964470295 @default.
- W2065962160 cites W1969259113 @default.
- W2065962160 cites W1972328487 @default.
- W2065962160 cites W1973055895 @default.
- W2065962160 cites W1973765221 @default.
- W2065962160 cites W1977860760 @default.
- W2065962160 cites W1983252720 @default.
- W2065962160 cites W1983967034 @default.
- W2065962160 cites W1984660568 @default.
- W2065962160 cites W1987521590 @default.
- W2065962160 cites W1994812203 @default.
- W2065962160 cites W2001954021 @default.
- W2065962160 cites W2005645048 @default.
- W2065962160 cites W2010723168 @default.
- W2065962160 cites W2013427111 @default.
- W2065962160 cites W2020619883 @default.
- W2065962160 cites W2023448021 @default.
- W2065962160 cites W2025603247 @default.
- W2065962160 cites W2030773781 @default.
- W2065962160 cites W2033066077 @default.
- W2065962160 cites W2034823585 @default.
- W2065962160 cites W2039265322 @default.
- W2065962160 cites W2040884624 @default.
- W2065962160 cites W2046855179 @default.
- W2065962160 cites W2047565355 @default.
- W2065962160 cites W2055551927 @default.
- W2065962160 cites W2066664059 @default.
- W2065962160 cites W2067883893 @default.
- W2065962160 cites W2075385578 @default.
- W2065962160 cites W2079407277 @default.
- W2065962160 cites W2082056883 @default.
- W2065962160 cites W2083547018 @default.
- W2065962160 cites W2085026965 @default.
- W2065962160 cites W2090719061 @default.
- W2065962160 cites W2090996828 @default.
- W2065962160 cites W2096006516 @default.
- W2065962160 cites W2097965856 @default.
- W2065962160 cites W2105402392 @default.
- W2065962160 cites W2107514471 @default.
- W2065962160 cites W2110442840 @default.
- W2065962160 cites W2110684391 @default.
- W2065962160 cites W2113547127 @default.
- W2065962160 cites W2118915904 @default.
- W2065962160 cites W2120529907 @default.
- W2065962160 cites W2121642311 @default.
- W2065962160 cites W2122322641 @default.
- W2065962160 cites W2122440289 @default.
- W2065962160 cites W2123673927 @default.
- W2065962160 cites W2125224248 @default.
- W2065962160 cites W2125248031 @default.
- W2065962160 cites W2129765787 @default.
- W2065962160 cites W2134519472 @default.
- W2065962160 cites W2135869210 @default.
- W2065962160 cites W2136680209 @default.
- W2065962160 cites W2142875089 @default.
- W2065962160 cites W2143935514 @default.
- W2065962160 cites W2159117162 @default.
- W2065962160 cites W2168882317 @default.
- W2065962160 cites W2169154493 @default.
- W2065962160 cites W2171269012 @default.
- W2065962160 cites W2299687596 @default.
- W2065962160 cites W4206144694 @default.
- W2065962160 cites W4211041495 @default.
- W2065962160 doi "https://doi.org/10.1016/j.neuroscience.2008.09.020" @default.
- W2065962160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2802129" @default.
- W2065962160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18854207" @default.
- W2065962160 hasPublicationYear "2008" @default.
- W2065962160 type Work @default.
- W2065962160 sameAs 2065962160 @default.
- W2065962160 citedByCount "77" @default.
- W2065962160 countsByYear W20659621602012 @default.
- W2065962160 countsByYear W20659621602013 @default.
- W2065962160 countsByYear W20659621602014 @default.
- W2065962160 countsByYear W20659621602015 @default.
- W2065962160 countsByYear W20659621602016 @default.
- W2065962160 countsByYear W20659621602017 @default.
- W2065962160 countsByYear W20659621602018 @default.
- W2065962160 countsByYear W20659621602019 @default.
- W2065962160 countsByYear W20659621602020 @default.
- W2065962160 countsByYear W20659621602021 @default.
- W2065962160 countsByYear W20659621602022 @default.
- W2065962160 crossrefType "journal-article" @default.
- W2065962160 hasAuthorship W2065962160A5017700541 @default.
- W2065962160 hasAuthorship W2065962160A5052012618 @default.
- W2065962160 hasAuthorship W2065962160A5070864680 @default.
- W2065962160 hasAuthorship W2065962160A5075336895 @default.