FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065978971> ?p ?o ?g. }

• W2065978971 endingPage "347" @default.
• W2065978971 startingPage "339" @default.
• W2065978971 abstract "The interaction of reducing sugars, such as aldose, with proteins and the subsequent molecular rearrangements, produces irreversible advanced glycation end-products (AGEs), a heterogeneous class of non-enzymatic glycated proteins or lipids. AGEs form cross-links, trap macromolecules and release reactive oxygen intermediates. AGEs are linked to aging, and increase in several related diseases. The aim of this study was to assess, in a murine macrophage cell line, J774A.1, the effects of 48 h of exposure to glycated serum containing a known amount of pentosidine, a well-known AGE found in the plasma and tissues of diabetic and uremic subjects. Fetal bovine serum was incubated with ribose (50 mm) for 7 days at 37 °C to obtain about 10 nmol/ml of pentosidine. The cytotoxic parameters studied were cell morphology and viability by neutral red uptake, lactate dehydrogenase release and tetrazolium salt test. In the medium and in the intracellular compartment, bound and free pentosidine were evaluated by HPLC, as sensitive and specific glycative markers, and thiobarbituric acid reactive substances (TBARs), as index of the extent of lipid peroxidation. Our results confirm that macrophages are able to take up pentosidine. It is conceivable that bound pentosidine is degraded and free pentosidine is released inside the cell and then into the medium. The AGE increase in the medium was combined with an increase in TBARs, meaning that an oxidative stress occurred; marked cytotoxic effects were observed, and were followed by the release of free pentosidine and TBARs into the culture medium." @default.
• W2065978971 created "2016-06-24" @default.
• W2065978971 creator A5006023626 @default.
• W2065978971 creator A5020546215 @default.
• W2065978971 creator A5028681335 @default.
• W2065978971 creator A5034125331 @default.
• W2065978971 creator A5052047001 @default.
• W2065978971 creator A5057793702 @default.
• W2065978971 creator A5073308283 @default.
• W2065978971 date "2002-08-01" @default.
• W2065978971 modified "2023-09-26" @default.
• W2065978971 title "Damaging effects of advanced glycation end-products in the murine macrophage cell line J774A.1" @default.
• W2065978971 cites W1503291459 @default.
• W2065978971 cites W1594856996 @default.
• W2065978971 cites W1762471665 @default.
• W2065978971 cites W1965076280 @default.
• W2065978971 cites W1967582415 @default.
• W2065978971 cites W1968214729 @default.
• W2065978971 cites W1968251204 @default.
• W2065978971 cites W1969937538 @default.
• W2065978971 cites W1977733762 @default.
• W2065978971 cites W1985130074 @default.
• W2065978971 cites W1986618252 @default.
• W2065978971 cites W1987846783 @default.
• W2065978971 cites W1988591283 @default.
• W2065978971 cites W1989148773 @default.
• W2065978971 cites W1998498936 @default.
• W2065978971 cites W2003742797 @default.
• W2065978971 cites W2011824272 @default.
• W2065978971 cites W2012945186 @default.
• W2065978971 cites W2014671896 @default.
• W2065978971 cites W2024187397 @default.
• W2065978971 cites W2026782054 @default.
• W2065978971 cites W2036699544 @default.
• W2065978971 cites W2044327338 @default.
• W2065978971 cites W2047964022 @default.
• W2065978971 cites W2048643443 @default.
• W2065978971 cites W2066474646 @default.
• W2065978971 cites W2066512884 @default.
• W2065978971 cites W2067829426 @default.
• W2065978971 cites W2070792620 @default.
• W2065978971 cites W2085341182 @default.
• W2065978971 cites W2088686339 @default.
• W2065978971 cites W2089878313 @default.
• W2065978971 cites W2111867309 @default.
• W2065978971 cites W2113311606 @default.
• W2065978971 cites W2114918609 @default.
• W2065978971 cites W2117692528 @default.
• W2065978971 cites W2160234008 @default.
• W2065978971 cites W2161888004 @default.
• W2065978971 cites W2330436374 @default.
• W2065978971 cites W4235552555 @default.
• W2065978971 cites W4237204216 @default.
• W2065978971 cites W4239792441 @default.
• W2065978971 cites W4293247451 @default.
• W2065978971 doi "https://doi.org/10.1016/s0887-2333(02)00016-4" @default.
• W2065978971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12110271" @default.
• W2065978971 hasPublicationYear "2002" @default.
• W2065978971 type Work @default.
• W2065978971 sameAs 2065978971 @default.
• W2065978971 citedByCount "16" @default.
• W2065978971 countsByYear W20659789712012 @default.
• W2065978971 countsByYear W20659789712013 @default.
• W2065978971 countsByYear W20659789712014 @default.
• W2065978971 countsByYear W20659789712015 @default.
• W2065978971 crossrefType "journal-article" @default.
• W2065978971 hasAuthorship W2065978971A5006023626 @default.
• W2065978971 hasAuthorship W2065978971A5020546215 @default.
• W2065978971 hasAuthorship W2065978971A5028681335 @default.
• W2065978971 hasAuthorship W2065978971A5034125331 @default.
• W2065978971 hasAuthorship W2065978971A5052047001 @default.
• W2065978971 hasAuthorship W2065978971A5057793702 @default.
• W2065978971 hasAuthorship W2065978971A5073308283 @default.
• W2065978971 hasConcept C126322002 @default.
• W2065978971 hasConcept C134018914 @default.
• W2065978971 hasConcept C147990577 @default.
• W2065978971 hasConcept C170493617 @default.
• W2065978971 hasConcept C181199279 @default.
• W2065978971 hasConcept C185592680 @default.
• W2065978971 hasConcept C2776151105 @default.
• W2065978971 hasConcept C2776997535 @default.
• W2065978971 hasConcept C2777318727 @default.
• W2065978971 hasConcept C2777352226 @default.
• W2065978971 hasConcept C2777504301 @default.
• W2065978971 hasConcept C2780758796 @default.
• W2065978971 hasConcept C2780829032 @default.
• W2065978971 hasConcept C55493867 @default.
• W2065978971 hasConcept C71924100 @default.
• W2065978971 hasConcept C86803240 @default.
• W2065978971 hasConceptScore W2065978971C126322002 @default.
• W2065978971 hasConceptScore W2065978971C134018914 @default.
• W2065978971 hasConceptScore W2065978971C147990577 @default.
• W2065978971 hasConceptScore W2065978971C170493617 @default.
• W2065978971 hasConceptScore W2065978971C181199279 @default.
• W2065978971 hasConceptScore W2065978971C185592680 @default.
• W2065978971 hasConceptScore W2065978971C2776151105 @default.
• W2065978971 hasConceptScore W2065978971C2776997535 @default.
• W2065978971 hasConceptScore W2065978971C2777318727 @default.

• next