FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065987181> ?p ?o ?g. }

• W2065987181 endingPage "2006" @default.
• W2065987181 startingPage "2000" @default.
• W2065987181 abstract "Cannabinoids confer neuroprotection in several experimental paradigms, but the responsible mechanisms remain unknown. Therefore, we sought to examine whether the synthetic CB1 agonist HU-210 is capable of reducing ischemic damage and to determine the mechanisms responsible for such protection.Sprague-Dawley rats underwent permanent middle cerebral artery occlusion (PMCAO). After dose-response and therapeutic time window-finding experiments, the rats were injected with HU-210 (45 microg/kg IV) or vehicle 1 hour after PMCAO. Physiological parameters and cerebral blood flow in the peri-infarct zone were monitored. The animals were examined with a motor disability scale, and the infarct volumes were measured 72 hours later. We also examined the effects of the selective CB1 antagonist SR-141716 and of controlled warming on the neuroprotection conferred by HU-210.HU-210 reduced blood pressure and heart rate but did not alter the cerebral blood flow in the infarct border zone. Motor disability and infarct volumes were significantly reduced (by up to 77%; P<0.05) in animals treated with HU-210. A single injection of HU-210 significantly lowered the body temperature compared with vehicle as measured both at 1 hour (32.3+/-1.3 degrees C versus 35+/-1.6 degrees C; P=0.0024) and at 24 hours (31.5+/-2.5 degrees C versus 37.25+/-0.3 degrees C; P=0.0031) after PMCAO. The protective effects of HU-210 were partially reversed by pretreatment with SR-141716 but were completely abolished by warming of the animals to the levels observed in controls.HU-210 confers robust protection against ischemic damage. This protection is mediated at least in part by binding to CB1 receptors and is also associated with the indirect protective effects of hypothermia." @default.
• W2065987181 created "2016-06-24" @default.
• W2065987181 creator A5014241454 @default.
• W2065987181 creator A5065631892 @default.
• W2065987181 creator A5070259129 @default.
• W2065987181 creator A5080846757 @default.
• W2065987181 date "2003-08-01" @default.
• W2065987181 modified "2023-10-06" @default.
• W2065987181 title "Drug-Induced Hypothermia Reduces Ischemic Damage" @default.
• W2065987181 cites W1931308193 @default.
• W2065987181 cites W1963874268 @default.
• W2065987181 cites W1965187012 @default.
• W2065987181 cites W1969478524 @default.
• W2065987181 cites W1973645562 @default.
• W2065987181 cites W1979051430 @default.
• W2065987181 cites W1987020838 @default.
• W2065987181 cites W1996568613 @default.
• W2065987181 cites W1997410543 @default.
• W2065987181 cites W1997734783 @default.
• W2065987181 cites W2015953188 @default.
• W2065987181 cites W2016083532 @default.
• W2065987181 cites W2016619600 @default.
• W2065987181 cites W2032715817 @default.
• W2065987181 cites W2036755665 @default.
• W2065987181 cites W2047180193 @default.
• W2065987181 cites W2048987473 @default.
• W2065987181 cites W2053070543 @default.
• W2065987181 cites W2063087507 @default.
• W2065987181 cites W2089955156 @default.
• W2065987181 cites W2092038789 @default.
• W2065987181 cites W2095621515 @default.
• W2065987181 cites W2098025305 @default.
• W2065987181 cites W2106514701 @default.
• W2065987181 cites W2111689088 @default.
• W2065987181 cites W2114932065 @default.
• W2065987181 cites W2161180285 @default.
• W2065987181 cites W2166889498 @default.
• W2065987181 cites W2326309321 @default.
• W2065987181 cites W4246201725 @default.
• W2065987181 doi "https://doi.org/10.1161/01.str.0000079817.68944.1e" @default.
• W2065987181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12829867" @default.
• W2065987181 hasPublicationYear "2003" @default.
• W2065987181 type Work @default.
• W2065987181 sameAs 2065987181 @default.
• W2065987181 citedByCount "115" @default.
• W2065987181 countsByYear W20659871812012 @default.
• W2065987181 countsByYear W20659871812013 @default.
• W2065987181 countsByYear W20659871812014 @default.
• W2065987181 countsByYear W20659871812015 @default.
• W2065987181 countsByYear W20659871812016 @default.
• W2065987181 countsByYear W20659871812017 @default.
• W2065987181 countsByYear W20659871812018 @default.
• W2065987181 countsByYear W20659871812019 @default.
• W2065987181 countsByYear W20659871812020 @default.
• W2065987181 countsByYear W20659871812021 @default.
• W2065987181 countsByYear W20659871812022 @default.
• W2065987181 countsByYear W20659871812023 @default.
• W2065987181 crossrefType "journal-article" @default.
• W2065987181 hasAuthorship W2065987181A5014241454 @default.
• W2065987181 hasAuthorship W2065987181A5065631892 @default.
• W2065987181 hasAuthorship W2065987181A5070259129 @default.
• W2065987181 hasAuthorship W2065987181A5080846757 @default.
• W2065987181 hasBestOaLocation W20659871811 @default.
• W2065987181 hasConcept C126322002 @default.
• W2065987181 hasConcept C127413603 @default.
• W2065987181 hasConcept C157767197 @default.
• W2065987181 hasConcept C158846371 @default.
• W2065987181 hasConcept C164705383 @default.
• W2065987181 hasConcept C170493617 @default.
• W2065987181 hasConcept C25498285 @default.
• W2065987181 hasConcept C2775841333 @default.
• W2065987181 hasConcept C2776885963 @default.
• W2065987181 hasConcept C2777390192 @default.
• W2065987181 hasConcept C2778938600 @default.
• W2065987181 hasConcept C2780645631 @default.
• W2065987181 hasConcept C42219234 @default.
• W2065987181 hasConcept C541997718 @default.
• W2065987181 hasConcept C71924100 @default.
• W2065987181 hasConcept C78519656 @default.
• W2065987181 hasConcept C98274493 @default.
• W2065987181 hasConceptScore W2065987181C126322002 @default.
• W2065987181 hasConceptScore W2065987181C127413603 @default.
• W2065987181 hasConceptScore W2065987181C157767197 @default.
• W2065987181 hasConceptScore W2065987181C158846371 @default.
• W2065987181 hasConceptScore W2065987181C164705383 @default.
• W2065987181 hasConceptScore W2065987181C170493617 @default.
• W2065987181 hasConceptScore W2065987181C25498285 @default.
• W2065987181 hasConceptScore W2065987181C2775841333 @default.
• W2065987181 hasConceptScore W2065987181C2776885963 @default.
• W2065987181 hasConceptScore W2065987181C2777390192 @default.
• W2065987181 hasConceptScore W2065987181C2778938600 @default.
• W2065987181 hasConceptScore W2065987181C2780645631 @default.
• W2065987181 hasConceptScore W2065987181C42219234 @default.
• W2065987181 hasConceptScore W2065987181C541997718 @default.
• W2065987181 hasConceptScore W2065987181C71924100 @default.
• W2065987181 hasConceptScore W2065987181C78519656 @default.
• W2065987181 hasConceptScore W2065987181C98274493 @default.
• W2065987181 hasIssue "8" @default.

• next