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• W2065989504 abstract "Objective. This study was designed to clarify the internalization of anti‐DNA antibodies (anti‐DNA) into living cells in the pathogenesis of systemic lupus erythematosus (SLE) using anti‐DNA monoclonal antibodies (mAbs). Methods. Anti‐DNA mAbs 9D7, 9D7D2, 9A4, 5E3F5, 12B3H2 and 6E11E3 were prepared by a standard hybridoma procedure to determine the interaction of anti‐DNA with proteins in different types of cells. Results. The anti‐DNA mAbs reacted with two protein antigens (35 and 50 kDa) in the cells. The 35‐kDa antigen was shown to have 100% homology with hnRNP A2. The arginine–glycine‐rich domain in hnRNP A2 was found to be the reaction site, and the methylation of hnRNP A2 by PRMT1 (protein arginine methyltransferase 1) was increased by anti‐DNA. Moreover, anti‐DNA was demonstrated to bind and internalize into the cytoplasm and nucleus. Conclusion. Nuclear localizing anti‐DNA may cross‐react with hnRNP A2 to modulate the inflammatory responses and polarize immune reactions associated with SLE." @default.
• W2065989504 created "2016-06-24" @default.
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• W2065989504 date "2003-01-01" @default.
• W2065989504 modified "2023-10-16" @default.
• W2065989504 title "Autoantibodies to dsDNA cross-react with the arginine-glycine-rich domain of heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) and promote methylation of hnRNP A2" @default.
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• W2065989504 doi "https://doi.org/10.1093/rheumatology/keg060" @default.
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