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- W2065992716 abstract "Endocannabinoids (eCBs) function as retrograde messengers at both excitatory and inhibitory synapses, and control various forms of synaptic plasticity in the adult brain. The molecular machinery required for specific eCB functions during synaptic plasticity is well established. However, eCB signaling plays surprisingly fundamental roles in controlling the acquisition of neuronal identity during CNS development. Recent work suggests that selective recruitment of regulatory signaling networks to CB1 cannabinoid receptors dictates neuronal state-change decisions. In addition, the spatial localization and temporal precision of eCB actions emerges as a novel organizer in developing neuronal networks. Current challenges include fitting novel molecular candidates into regulatory eCB signaling pathways, and defining the temporal dynamics of context-dependent signaling mechanisms underpinning particular neuronal specification events." @default.
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- W2065992716 date "2008-06-01" @default.
- W2065992716 modified "2023-10-11" @default.
- W2065992716 title "Wiring and firing neuronal networks: endocannabinoids take center stage" @default.
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- W2065992716 doi "https://doi.org/10.1016/j.conb.2008.08.007" @default.
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