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• W2065996968 abstract "Two general pathological processes contribute to multiple sclerosis (MS): acute inflammation and degeneration. While magnetic resonance imaging (MRI) is highly sensitive in detecting abnormalities related to acute inflammation both clinically and in animal models of experimental autoimmune encephalomyelitis (EAE), the correlation of these readouts with acute and future disabilities has been found rather weak. This illustrates the need for imaging techniques addressing neurodegenerative processes associated with MS. In the present work we evaluated the sensitivity of different MRI techniques (T 2 mapping, macrophage tracking based on labeling cells in vivo by ultrasmall particles of iron oxide (USPIO), diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI)) to detect histopathological changes in a novel animal model making use of intrinsic, temporally and spatially controlled triggering of oligodendrocyte cell death. This mouse model allows studying the MRI signature associated to neurodegenerative processes of MS in the absence of adaptive inflammatory components that appear to be foremost in the EAE models. Our results revealed pronounced T 2 hyperintensities in brain stem and cerebellar structures, which we attribute to structural alteration of white matter by pronounced vacuolation. Brain areas were found devoid of significant macrophage infiltration in line with the absence of a peripheral inflammatory response. The significant decrease in diffusion anisotropy derived from DTI measures in these structures is mainly caused by a pronounced decrease in diffusivity parallel to the fiber indicative of axonal damage. Triggering of oligodendrocyte ablation did not translate into a significant increase in radial diffusivity. Only minor decreases in MT ratio have been observed, which is attributed to inefficient removal of myelin debris. ► Animal model of oligodendrocyte cell death in the absence of adaptive inflammation. ► Pronounced T 2 hyperintensities in brain attributed to vacuolation in white matter. ► No macrophage infiltration reflects absence of a peripheral inflammatory response. ► Decrease in diffusion anisotropy is mainly due to axonal damage. ► Triggering of oligodendrocyte ablation did not affect radial diffusivity." @default.
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• W2065996968 date "2012-01-01" @default.
• W2065996968 modified "2023-09-27" @default.
• W2065996968 title "MRI signature in a novel mouse model of genetically induced adult oligodendrocyte cell death" @default.
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• W2065996968 doi "https://doi.org/10.1016/j.neuroimage.2011.09.001" @default.
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