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- W2065998211 abstract "A new conflict procedure was developed to study the potential anti-punishment effects of 5-HT 1A agonists as compared to diazepam. In this paradigm, the opportunity existed for rats to choose during punished periods between immediate, punished reinforcement and delayed, non-punished reinforcement. The results confirm that, for non-sedative doses (1 mg/kg), diazepam increases the number of punished responses. Furthermore, the present paradigm seems sensitive for the detection of 5-HT 1A activity. Buspirone, gepirone, ipsapirone, zalospirone and 8-OH-DPAT increased responding for immediate but punished reinforcement. 1-(2-pyrimidinyl)piperazine, the common metabolite of the azapirones, does not participate in their anti-conflict effect. NAN 190, a 5-HT 1A antagonist, was shown to block the 5-HT 1A agonists. The findings of the present study suggest that benzodiazepines and 5-HT 1A agonists reduce the capacity to tolerate delays in reward. Abnormality in serotonin systems may be associated with poor impulse control." @default.
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- W2065998211 date "1994-07-01" @default.
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- W2065998211 title "Anti-conflict effect of 5-HT1A agonists in rats: a new model for evaluating anxiolytic-like activity" @default.
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- W2065998211 doi "https://doi.org/10.1177/026988119400800406" @default.
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