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- W2066007306 abstract "The effect of the meglitinide analog S21403 (10 microm) upon(86)Rb and(45)Ca outflow and insulin release was investigated in perifused rat islets exposed to a high concentration of D-glucose (16.7 mm) in order to simulate the situation found in diabetic patients. Under these conditions, S21403 provoked a rapid, sustained and rapidly reversible increase in(86)Rb outflow, (45)Ca efflux and insulin release. These effects were suppressed or reversed when the experiments were conducted in the absence of extracellular Ca2+. They support the view that S21043 could be used as a novel insulinotropic tool in the treatment of non-insulin-dependent diabetes mellitus, the cationic and secretory responses to the drug displaying a favourable time course for prompt and not unduly prolonged activation of islet B-cells." @default.
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- W2066007306 date "1999-09-01" @default.
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- W2066007306 title "EFFECT OF THE MEGLITINIDE ANALOG S214O3 ON CATIONIC FLUXES AND INSULIN RELEASE IN PERIFUSED RAT PANCREATIC ISLETS EXPOSED TO A HIGH CONCENTRATION OF D-GLUCOSE" @default.
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- W2066007306 doi "https://doi.org/10.1006/phrs.1999.0513" @default.
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