FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066009595> ?p ?o ?g. }

• W2066009595 endingPage "27" @default.
• W2066009595 startingPage "20" @default.
• W2066009595 abstract "The R6/2 mouse is the most common mouse model used for Huntington's disease (HD), a fatal, inherited neurodegenerative CAG disorder characterized by marked brain atrophy. We scanned 47 R6/2 transgenic and 42 wildtype (WT) ex vivo mouse brains at 18 weeks of age using high resolution, three-dimensional magnetic resonance imaging (MRI) for automated voxel-based morphometry (VBM) analysis. We found differences between genotypes in specific brain structures. Many of these changes were bilateral and were found in regions known to be involved in the behavioral deficits present in both R6/2 mice and HD patients. In particular, changes were evident in the basal ganglia, hippocampus, cortex and hypothalamus. In the striatum, changes were heterogenous and reminiscent of striosomal distribution. Changes were also seen in the cerebellum, as might be expected in a mouse carrying a repeat length typical of juvenile onset HD. Many of these changes were not detected by manual 2D morphometry from the same MR images. These data indicate that VBM will be a valuable technique for in vivo measurement of developing pathology in HD transgenic mice, and may be particularly useful for correlating histologically undetectable changes with behavioral deficits." @default.
• W2066009595 created "2016-06-24" @default.
• W2066009595 creator A5034026989 @default.
• W2066009595 creator A5034431716 @default.
• W2066009595 creator A5053246745 @default.
• W2066009595 creator A5071711769 @default.
• W2066009595 creator A5081316808 @default.
• W2066009595 date "2009-01-01" @default.
• W2066009595 modified "2023-10-06" @default.
• W2066009595 title "Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry" @default.
• W2066009595 cites W1651597776 @default.
• W2066009595 cites W1966865971 @default.
• W2066009595 cites W1967964206 @default.
• W2066009595 cites W1971316923 @default.
• W2066009595 cites W1973765221 @default.
• W2066009595 cites W1985050276 @default.
• W2066009595 cites W1994188899 @default.
• W2066009595 cites W1995119071 @default.
• W2066009595 cites W1996535168 @default.
• W2066009595 cites W2001469430 @default.
• W2066009595 cites W2009115851 @default.
• W2066009595 cites W2015852090 @default.
• W2066009595 cites W2017645644 @default.
• W2066009595 cites W2027024686 @default.
• W2066009595 cites W2028005691 @default.
• W2066009595 cites W2036142047 @default.
• W2066009595 cites W2062682951 @default.
• W2066009595 cites W2063113866 @default.
• W2066009595 cites W2064358322 @default.
• W2066009595 cites W2075050732 @default.
• W2066009595 cites W2086884518 @default.
• W2066009595 cites W2087328731 @default.
• W2066009595 cites W2087820899 @default.
• W2066009595 cites W2100512259 @default.
• W2066009595 cites W2105456967 @default.
• W2066009595 cites W2107522917 @default.
• W2066009595 cites W2110402512 @default.
• W2066009595 cites W2110715131 @default.
• W2066009595 cites W2119848633 @default.
• W2066009595 cites W2126087211 @default.
• W2066009595 cites W2126357344 @default.
• W2066009595 cites W2128575158 @default.
• W2066009595 cites W2138146369 @default.
• W2066009595 cites W2146280007 @default.
• W2066009595 cites W2146469513 @default.
• W2066009595 cites W2148079076 @default.
• W2066009595 cites W2154108863 @default.
• W2066009595 cites W2156875677 @default.
• W2066009595 cites W2159050691 @default.
• W2066009595 cites W2163274894 @default.
• W2066009595 cites W2328251192 @default.
• W2066009595 cites W255725710 @default.
• W2066009595 cites W4206144694 @default.
• W2066009595 cites W4230920194 @default.
• W2066009595 doi "https://doi.org/10.1016/j.nbd.2008.09.016" @default.
• W2066009595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18930824" @default.
• W2066009595 hasPublicationYear "2009" @default.
• W2066009595 type Work @default.
• W2066009595 sameAs 2066009595 @default.
• W2066009595 citedByCount "141" @default.
• W2066009595 countsByYear W20660095952012 @default.
• W2066009595 countsByYear W20660095952013 @default.
• W2066009595 countsByYear W20660095952014 @default.
• W2066009595 countsByYear W20660095952015 @default.
• W2066009595 countsByYear W20660095952016 @default.
• W2066009595 countsByYear W20660095952017 @default.
• W2066009595 countsByYear W20660095952018 @default.
• W2066009595 countsByYear W20660095952019 @default.
• W2066009595 countsByYear W20660095952020 @default.
• W2066009595 countsByYear W20660095952021 @default.
• W2066009595 countsByYear W20660095952022 @default.
• W2066009595 countsByYear W20660095952023 @default.
• W2066009595 crossrefType "journal-article" @default.
• W2066009595 hasAuthorship W2066009595A5034026989 @default.
• W2066009595 hasAuthorship W2066009595A5034431716 @default.
• W2066009595 hasAuthorship W2066009595A5053246745 @default.
• W2066009595 hasAuthorship W2066009595A5071711769 @default.
• W2066009595 hasAuthorship W2066009595A5081316808 @default.
• W2066009595 hasConcept C102230213 @default.
• W2066009595 hasConcept C104317684 @default.
• W2066009595 hasConcept C105702510 @default.
• W2066009595 hasConcept C126838900 @default.
• W2066009595 hasConcept C141035611 @default.
• W2066009595 hasConcept C142724271 @default.
• W2066009595 hasConcept C143409427 @default.
• W2066009595 hasConcept C145940234 @default.
• W2066009595 hasConcept C169760540 @default.
• W2066009595 hasConcept C200134340 @default.
• W2066009595 hasConcept C2777348757 @default.
• W2066009595 hasConcept C2778187257 @default.
• W2066009595 hasConcept C2779134260 @default.
• W2066009595 hasConcept C2779652256 @default.
• W2066009595 hasConcept C2780062018 @default.
• W2066009595 hasConcept C2780647506 @default.
• W2066009595 hasConcept C2781161787 @default.
• W2066009595 hasConcept C2781172350 @default.
• W2066009595 hasConcept C2781192897 @default.
• W2066009595 hasConcept C513476851 @default.

• next