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- W2066015053 endingPage "366" @default.
- W2066015053 startingPage "353" @default.
- W2066015053 abstract "The inflammatory cytokine tumor necrosis factor (TNF), as well as most other ligand members of the TNF superfamily, exist both as classical soluble cytokines, but also in the form of type II transmembrane proteins. Both forms possess bioactivity, although some effects are distinct. In addition, an increasing body of evidence suggests that the membrane integrated ligands can receive signals, i.e. act as receptors which can transmit positive and negative feedback signals into the ligand bearing cell. Thus, reverse signaling enables a two-way communication in cell-to-cell signaling, and it is conceivable that this bi-directional signal exchange contributes to the plasticity of the ligand–receptor systems. Reverse signaling mainly has been observed in the immune system and within the TNF superfamily. Its function is only beginning to emerge warranting additional investigation, especially when it comes to therapeutic strategies involving cytokine modulation. This review provides an update of the literature about reverse signaling of transmembrane TNF family members and discusses its potential biological and clinical impact." @default.
- W2066015053 created "2016-06-24" @default.
- W2066015053 creator A5036674933 @default.
- W2066015053 creator A5038725238 @default.
- W2066015053 creator A5056350199 @default.
- W2066015053 date "2004-10-01" @default.
- W2066015053 modified "2023-10-02" @default.
- W2066015053 title "Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system" @default.
- W2066015053 cites W1481827372 @default.
- W2066015053 cites W1484817497 @default.
- W2066015053 cites W1490721606 @default.
- W2066015053 cites W1496012458 @default.
- W2066015053 cites W1496401613 @default.
- W2066015053 cites W1499561015 @default.
- W2066015053 cites W1501974073 @default.
- W2066015053 cites W1524470153 @default.
- W2066015053 cites W1534645474 @default.
- W2066015053 cites W1537714877 @default.
- W2066015053 cites W1544569979 @default.
- W2066015053 cites W1553927017 @default.
- W2066015053 cites W1566377812 @default.
- W2066015053 cites W1567369391 @default.
- W2066015053 cites W1598604401 @default.
- W2066015053 cites W1600048668 @default.
- W2066015053 cites W1625166229 @default.
- W2066015053 cites W163606371 @default.
- W2066015053 cites W1642812308 @default.
- W2066015053 cites W1758507680 @default.
- W2066015053 cites W1811909771 @default.
- W2066015053 cites W1922746363 @default.
- W2066015053 cites W1956977738 @default.
- W2066015053 cites W1964594655 @default.
- W2066015053 cites W1965783637 @default.
- W2066015053 cites W1966952488 @default.
- W2066015053 cites W1967642652 @default.
- W2066015053 cites W1967894078 @default.
- W2066015053 cites W1968295892 @default.
- W2066015053 cites W1969070574 @default.
- W2066015053 cites W1972437692 @default.
- W2066015053 cites W1973109581 @default.
- W2066015053 cites W1975992464 @default.
- W2066015053 cites W1976123727 @default.
- W2066015053 cites W1981306008 @default.
- W2066015053 cites W1985720487 @default.
- W2066015053 cites W1989279522 @default.
- W2066015053 cites W1991212304 @default.
- W2066015053 cites W1991508388 @default.
- W2066015053 cites W1994479908 @default.
- W2066015053 cites W1994504877 @default.
- W2066015053 cites W1995819749 @default.
- W2066015053 cites W2002507218 @default.
- W2066015053 cites W2003634544 @default.
- W2066015053 cites W2004159506 @default.
- W2066015053 cites W2006929002 @default.
- W2066015053 cites W2013994536 @default.
- W2066015053 cites W2020600328 @default.
- W2066015053 cites W2022452373 @default.
- W2066015053 cites W2023006000 @default.
- W2066015053 cites W2023395434 @default.
- W2066015053 cites W2026665503 @default.
- W2066015053 cites W2028111124 @default.
- W2066015053 cites W2028809209 @default.
- W2066015053 cites W2032386695 @default.
- W2066015053 cites W2038204617 @default.
- W2066015053 cites W2044610904 @default.
- W2066015053 cites W2052300492 @default.
- W2066015053 cites W2052398986 @default.
- W2066015053 cites W2052720090 @default.
- W2066015053 cites W2054991963 @default.
- W2066015053 cites W2055494409 @default.
- W2066015053 cites W2062528530 @default.
- W2066015053 cites W2064773328 @default.
- W2066015053 cites W2065125503 @default.
- W2066015053 cites W2067534266 @default.
- W2066015053 cites W2067567916 @default.
- W2066015053 cites W2068103783 @default.
- W2066015053 cites W2068765603 @default.
- W2066015053 cites W2072380594 @default.
- W2066015053 cites W2072738451 @default.
- W2066015053 cites W2074881372 @default.
- W2066015053 cites W2078254067 @default.
- W2066015053 cites W2078366306 @default.
- W2066015053 cites W2085631624 @default.
- W2066015053 cites W2086255604 @default.
- W2066015053 cites W2086860754 @default.
- W2066015053 cites W2087339935 @default.
- W2066015053 cites W2087501418 @default.
- W2066015053 cites W2088291142 @default.
- W2066015053 cites W2094882780 @default.
- W2066015053 cites W2095013915 @default.
- W2066015053 cites W2095328184 @default.
- W2066015053 cites W2097531560 @default.
- W2066015053 cites W2097957459 @default.
- W2066015053 cites W2098330694 @default.
- W2066015053 cites W2102585554 @default.
- W2066015053 cites W2106284224 @default.
- W2066015053 cites W2106821179 @default.
- W2066015053 cites W2107474918 @default.