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• W2066017618 abstract "The immunohistochemical activities of nitric oxide synthase (NOS), xanthine oxidase(XO) and nitrotyrosine(NT) in human radicular cysts were measured. The molecular interactions of nitric oxide (NO) or peroxynitrate(ONOO-) and superoxide(O2- •) generated in the xanthine/XO system were kinetically investigated in vitro to clarify the mechanism of tissue injury. To investigate the interaction between NO • and O2- • generated in radicular cysts, the localization of NOS and XO was evaluated by an immunohistochemical staining method. Furthermore, the presence of ONOO- was immunohistochemically estimated. The molecular interactions of O2- •, NO • and ONOO- were analyzed by using the electron spin resonance spin-trapping method. In an area of inflammatory reaction, human-inducible NOS (iNOS), XO and NT were positive compared with a normal area, although only iNOS production was confirmed an area of fibrous reaction. Kinetic studies showed that 1-hydroxy-2-oxo-3 (N-methyl-3-aminopropyl)-3-methyl-1-triazene (NOC-7) reacted directly with O2- •, whereas ONOO- did not react with O2- • but inhibited XO directly. The close involvement of iNOS production in the inflammatory region and the influence of the inflammatory reaction with both NO • production from iNOS and O2- • production from XO were suggested. The presence of iNOS in cysts suggests that NO • produced in periapical lesions plays an important role in the regulation of chronic lesions via the reaction with O2- • produced catalyzed by XO. From the reaction with O2- •, and NO • generated by the iNOS system, the formation of ONOO- and its direct inhibition of XO activity decreased the amount of O2- • produced and as a result inhibited the continued formation of ONOO-." @default.
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• W2066017618 date "2005-01-01" @default.
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• W2066017618 title "The Roles of Human-Inducible Nitric Oxide Synthase and Xanthine Oxidase in Regulating Chronic Inflammation in Radicular Cysts" @default.
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• W2066017618 doi "https://doi.org/10.5466/ijoms.3.149" @default.
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