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• W2066024172 startingPage "1004" @default.
• W2066024172 abstract "MicroRNAs (miRNAs) represent important regulators of gene expression besides transcriptional control. miRNA regulation can be involved in the cell developmental fate decisions, but can also have more subtle roles in buffering stochastic fluctuations in gene expression. They participate in pathways fundamental to B-cell development like B-cell receptor (BCR) signalling, B-cell migration/adhesion, cell-cell interactions in immune niches, and the production and class-switching of immunoglobulins. miRNAs influence B-cell maturation, generation of pre-, marginal zone, follicular, B1, plasma and memory B cells. In this review, we discuss miRNAs with essential functions in malignant B-cell development (such as miR-150, miR-155, miR-21, miR-34a, miR-17-92 and miR-15-16). We also put these miRNAs in the context of normal B-cell differentiation, as this is intimately connected to neoplastic B-cell development. We review miRNAs' role in the most common B-cell malignancies, including chronic lymphocytic leukaemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and mantle cell lymphoma (MCL). We focus on miR-contribution to the regulation of important signalling pathways (such as NF-κB, PI3K/AKT and TGF-β), BCR signalling and its modulators (such as PTEN, SHIP-1, ZAP-70, GAB1 and BTK), anti- and pro-apoptotic proteins (such as BCL2, MCL1, TCL1, BIM, p53 and SIRT1) and transcription factors (such as MYC, MYB, PU.1, FOXP1 and BCL6). We also discuss the association of miRNAs' expression levels with the patients' survival and response to therapy, summarizing their potential use as predictive and prognostic markers. Importantly, the targeting of miRNAs (like use of anti-miR-155 or miR-34a mimic) could provide a novel therapeutic approach as evidenced by tumour regression in xenograft mouse models and initial promising data from clinical trials." @default.
• W2066024172 created "2016-06-24" @default.
• W2066024172 creator A5024829432 @default.
• W2066024172 creator A5038868486 @default.
• W2066024172 date "2014-12-26" @default.
• W2066024172 modified "2023-10-18" @default.
• W2066024172 title "MicroRNAs in B-cell lymphomas: how a complex biology gets more complex" @default.
• W2066024172 cites W1511075797 @default.
• W2066024172 cites W1534033361 @default.
• W2066024172 cites W1878626643 @default.
• W2066024172 cites W1965298340 @default.
• W2066024172 cites W1965306643 @default.
• W2066024172 cites W1966052225 @default.
• W2066024172 cites W1966054625 @default.
• W2066024172 cites W1966116761 @default.
• W2066024172 cites W1966427699 @default.
• W2066024172 cites W1967007963 @default.
• W2066024172 cites W1967539215 @default.
• W2066024172 cites W1967705046 @default.
• W2066024172 cites W1969003435 @default.
• W2066024172 cites W1969008341 @default.
• W2066024172 cites W1971509320 @default.
• W2066024172 cites W1971615688 @default.
• W2066024172 cites W1972438884 @default.
• W2066024172 cites W1973292340 @default.
• W2066024172 cites W1979274352 @default.
• W2066024172 cites W1979849008 @default.
• W2066024172 cites W1984418367 @default.
• W2066024172 cites W1985563073 @default.
• W2066024172 cites W1986613820 @default.
• W2066024172 cites W1988163167 @default.
• W2066024172 cites W1992115508 @default.
• W2066024172 cites W1994455902 @default.
• W2066024172 cites W1994605118 @default.
• W2066024172 cites W1995204078 @default.
• W2066024172 cites W2000102678 @default.
• W2066024172 cites W2003628558 @default.
• W2066024172 cites W2004246503 @default.
• W2066024172 cites W2006173503 @default.
• W2066024172 cites W2006704637 @default.
• W2066024172 cites W2007430145 @default.
• W2066024172 cites W2014869583 @default.
• W2066024172 cites W2017481656 @default.
• W2066024172 cites W2018765113 @default.
• W2066024172 cites W2022772242 @default.
• W2066024172 cites W2023121881 @default.
• W2066024172 cites W2023628840 @default.
• W2066024172 cites W2024640284 @default.
• W2066024172 cites W2024704386 @default.
• W2066024172 cites W2025449301 @default.
• W2066024172 cites W2026570544 @default.
• W2066024172 cites W2028959659 @default.
• W2066024172 cites W2030712838 @default.
• W2066024172 cites W2033850456 @default.
• W2066024172 cites W2035918677 @default.
• W2066024172 cites W2036534625 @default.
• W2066024172 cites W2037180787 @default.
• W2066024172 cites W2038067635 @default.
• W2066024172 cites W2038149830 @default.
• W2066024172 cites W2041703425 @default.
• W2066024172 cites W2041714373 @default.
• W2066024172 cites W2044074863 @default.
• W2066024172 cites W2044127274 @default.
• W2066024172 cites W2045025406 @default.
• W2066024172 cites W2047119105 @default.
• W2066024172 cites W2050667838 @default.
• W2066024172 cites W2051564672 @default.
• W2066024172 cites W2051584801 @default.
• W2066024172 cites W2051888282 @default.
• W2066024172 cites W2056277981 @default.
• W2066024172 cites W2059878251 @default.
• W2066024172 cites W2060013333 @default.
• W2066024172 cites W2061958576 @default.
• W2066024172 cites W2062175368 @default.
• W2066024172 cites W2062290101 @default.
• W2066024172 cites W2067915426 @default.
• W2066024172 cites W2068004842 @default.
• W2066024172 cites W2068170042 @default.
• W2066024172 cites W2070651992 @default.
• W2066024172 cites W2072076620 @default.
• W2066024172 cites W2072559448 @default.
• W2066024172 cites W2072688209 @default.
• W2066024172 cites W2074277423 @default.
• W2066024172 cites W2074429834 @default.
• W2066024172 cites W2074882915 @default.
• W2066024172 cites W2075329854 @default.
• W2066024172 cites W2077408537 @default.
• W2066024172 cites W2079294041 @default.
• W2066024172 cites W2079625864 @default.
• W2066024172 cites W2080800490 @default.
• W2066024172 cites W2081117322 @default.
• W2066024172 cites W2082414447 @default.
• W2066024172 cites W2089274312 @default.
• W2066024172 cites W2091959384 @default.
• W2066024172 cites W2093963603 @default.
• W2066024172 cites W2100265671 @default.
• W2066024172 cites W2100389519 @default.
• W2066024172 cites W2106790562 @default.

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