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- W2066024935 abstract "Collagen is a major constituent of the extracellular matrix (ECM) of the early developing heart. The role of mature cross-linked collagen has not been demonstrated in cardiac morphogenesis, although investigators using other developmental systems have suggested that collagen can act as an inducer. The injection of 500 μg of BAPN (beta-aminopropionitrile fumurate), a known inhibitor of cross-linking, into the pericardial region of chick embryos prior to valvular and septal morphogenesis (Stage 12 to 14) was without effect on the appearance or migration of cushion tissue mesenchyme in the ECM. However, by Stage 22 to 23 BAPN-treated embryos exhibited truncal aneurysms which resulted in death. Ultrastructural examination of the hearts of BAPN-treated embryos showed an alteration in the cell surface of both the endocardium and myocardium as evidenced by the deposition of very electron dense material. Biochemical analysis confirmed that BAPN-treated organisms were indeed lathyritic. These studies suggest that the continued synthesis and deposition of mature cross-linked collagen is not required for initiation and migration of cushion tissue mesenchyme nor for the appearance and maintenance of specific endocardial shape changes referred to as “flutes”. It is suggested that collagen is primarily a structural macromolecule in the early heart, rather than an inducer. These studies further suggest that, in addition to its effect on collagen cross-linking, BAPN may cause cardiac anomalies by modifying collagen: proteoglycan interaction within the ECM." @default.
- W2066024935 created "2016-06-24" @default.
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- W2066024935 date "1980-06-01" @default.
- W2066024935 modified "2023-09-27" @default.
- W2066024935 title "Effects of beta-aminopropionitrile fumurate (BAPN) on early heart development" @default.
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- W2066024935 doi "https://doi.org/10.1016/0022-2828(80)90015-2" @default.
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