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- W2066025672 abstract "Advances in the understanding of multiple myeloma pathogenesis have led to the development of innovative targeted therapies and improved management of this aggressive hematological neoplasia. This review will focus on the clinical trials that have reinforced the use of these new agents. Also, we will briefly take a look at the newer drugs making their way out of the laboratory and into early phase studies.During the past decade new multiple myeloma therapies featuring bortezomib and lenalidomide have come to light, whereas known agents such as thalidomide and arsenic trioxide have been reintroduced as key factors in multiple myeloma management. These new agents and their combinations have shown increased response rates and have added more options for patients with multiple myeloma whose disease has become resistant to conventional therapy. With these drug therapies has come a more targeted approach to treatment enabling not only improved antimyeloma efficacy but also the use of decreased dosing enhancing the safety and tolerability of these regimens. Newer agents including the histone deacetylase, hsp90, mammalian target of rapamycin and Akt inhibitors are showing promise preclinically and are now being assessed in phase I/II trials.This new antimultiple myeloma arsenal has shown its worth in both the relapsed/refractory and frontline setting and provides valuable options for patients with this debilitating disease." @default.
- W2066025672 created "2016-06-24" @default.
- W2066025672 creator A5040835019 @default.
- W2066025672 creator A5048382573 @default.
- W2066025672 date "2008-09-01" @default.
- W2066025672 modified "2023-10-01" @default.
- W2066025672 title "New drugs in multiple myeloma" @default.
- W2066025672 cites W1597238753 @default.
- W2066025672 cites W1968557197 @default.
- W2066025672 cites W1970309861 @default.
- W2066025672 cites W1970734978 @default.
- W2066025672 cites W1980471295 @default.
- W2066025672 cites W1984949744 @default.
- W2066025672 cites W1992538067 @default.
- W2066025672 cites W1998071923 @default.
- W2066025672 cites W2004349505 @default.
- W2066025672 cites W2007998678 @default.
- W2066025672 cites W2010184965 @default.
- W2066025672 cites W2013647024 @default.
- W2066025672 cites W2013907250 @default.
- W2066025672 cites W2014922333 @default.
- W2066025672 cites W2019199838 @default.
- W2066025672 cites W2021954218 @default.
- W2066025672 cites W2023148609 @default.
- W2066025672 cites W2024969918 @default.
- W2066025672 cites W2025253157 @default.
- W2066025672 cites W2029499151 @default.
- W2066025672 cites W2034372485 @default.
- W2066025672 cites W2036343984 @default.
- W2066025672 cites W2046818057 @default.
- W2066025672 cites W2049457454 @default.
- W2066025672 cites W2052169053 @default.
- W2066025672 cites W2053875306 @default.
- W2066025672 cites W2060496777 @default.
- W2066025672 cites W2063266714 @default.
- W2066025672 cites W2066329342 @default.
- W2066025672 cites W2069373667 @default.
- W2066025672 cites W2070009086 @default.
- W2066025672 cites W2070227063 @default.
- W2066025672 cites W2072103198 @default.
- W2066025672 cites W2088489718 @default.
- W2066025672 cites W2093757149 @default.
- W2066025672 cites W2097331346 @default.
- W2066025672 cites W2104028456 @default.
- W2066025672 cites W2106783894 @default.
- W2066025672 cites W2107154392 @default.
- W2066025672 cites W2108235071 @default.
- W2066025672 cites W2108503700 @default.
- W2066025672 cites W2109635468 @default.
- W2066025672 cites W2109795454 @default.
- W2066025672 cites W2110027836 @default.
- W2066025672 cites W2110466835 @default.
- W2066025672 cites W2113101033 @default.
- W2066025672 cites W2117172636 @default.
- W2066025672 cites W2117807601 @default.
- W2066025672 cites W2118335184 @default.
- W2066025672 cites W2118820477 @default.
- W2066025672 cites W2120474651 @default.
- W2066025672 cites W2124018860 @default.
- W2066025672 cites W2124560610 @default.
- W2066025672 cites W2127760782 @default.
- W2066025672 cites W2129534936 @default.
- W2066025672 cites W2129662445 @default.
- W2066025672 cites W2136226957 @default.
- W2066025672 cites W2136795385 @default.
- W2066025672 cites W2142112710 @default.
- W2066025672 cites W2143844507 @default.
- W2066025672 cites W2144531125 @default.
- W2066025672 cites W2147649894 @default.
- W2066025672 cites W2148188974 @default.
- W2066025672 cites W2148672632 @default.
- W2066025672 cites W2150596051 @default.
- W2066025672 cites W2152333590 @default.
- W2066025672 cites W2156748957 @default.
- W2066025672 cites W2160088903 @default.
- W2066025672 cites W2162934657 @default.
- W2066025672 cites W2163572210 @default.
- W2066025672 cites W2166043738 @default.
- W2066025672 cites W2166427186 @default.
- W2066025672 cites W2168663436 @default.
- W2066025672 cites W2168929741 @default.
- W2066025672 cites W2242232812 @default.
- W2066025672 cites W2316160054 @default.
- W2066025672 cites W2339661511 @default.
- W2066025672 cites W2416048408 @default.
- W2066025672 cites W2470063969 @default.
- W2066025672 cites W2499402954 @default.
- W2066025672 cites W2549511714 @default.
- W2066025672 cites W2556475996 @default.
- W2066025672 cites W2559077555 @default.
- W2066025672 cites W2559890956 @default.
- W2066025672 cites W2564114766 @default.
- W2066025672 cites W2580586341 @default.
- W2066025672 cites W2583215460 @default.
- W2066025672 cites W2588637205 @default.
- W2066025672 cites W2592133263 @default.
- W2066025672 cites W2594918126 @default.
- W2066025672 cites W2596298905 @default.