FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066027939> ?p ?o ?g. }

• W2066027939 endingPage "9712" @default.
• W2066027939 startingPage "9703" @default.
• W2066027939 abstract "Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine, acting through the TNF-R1 and TNF-R2 receptors. The two receptors have been proposed to mediate distinct TNF-α effects in the CNS, TNF-R1 contributing to neuronal damage and TNF-R2 being neuroprotective. Whether TNF-α and its receptors play any role for neurogenesis in the adult brain is unclear. Here we used mouse models with loss of TNF-R1 and TNF-R2 function to establish whether signaling through these receptors could influence hippocampal neurogenesis in vivo under basal conditions, as well as after status epilepticus (SE), which is associated with inflammation and elevated TNF-α levels. Notably, in the intact brain, the number of new, mature hippocampal neurons was elevated in TNF-R1 −/− and TNF-R1/R2 −/− mice, whereas no significant changes were detected in TNF-R2 −/− mice. Also after SE, the TNF-R1 −/− and TNF-R1/R2 −/− mice produced more new neurons. In contrast, the TNF-R2 −/− mice showed reduced SE-induced neurogenesis. Cell proliferation in the dentate subgranular zone was elevated in TNF-R1 −/− and TNF-R1/R2 −/− mice both under basal conditions and after SE. The TNF-R2 −/− mice either showed no change or minor decrease of cell proliferation. TNF-R1 and TNF-R2 receptors were expressed by hippocampal progenitors, as assessed with reverse transcription-PCR on sorted or cultured cells and immunocytochemistry on cultures. Our data reveal differential actions of TNF-R1 and TNF-R2 signaling in adult hippocampal neurogenesis and identify for the first time TNF-R1 as a negative regulator of neural progenitor proliferation in both the intact and pathological brain." @default.
• W2066027939 created "2016-06-24" @default.
• W2066027939 creator A5009107221 @default.
• W2066027939 creator A5012111660 @default.
• W2066027939 creator A5046090769 @default.
• W2066027939 creator A5046983952 @default.
• W2066027939 creator A5047651170 @default.
• W2066027939 creator A5066365730 @default.
• W2066027939 creator A5077289778 @default.
• W2066027939 creator A5086175851 @default.
• W2066027939 date "2006-09-20" @default.
• W2066027939 modified "2023-10-10" @default.
• W2066027939 title "Tumor Necrosis Factor Receptor 1 Is a Negative Regulator of Progenitor Proliferation in Adult Hippocampal Neurogenesis" @default.
• W2066027939 cites W1509596990 @default.
• W2066027939 cites W1724950598 @default.
• W2066027939 cites W1926095516 @default.
• W2066027939 cites W1968295892 @default.
• W2066027939 cites W1971004772 @default.
• W2066027939 cites W1975004539 @default.
• W2066027939 cites W1977667876 @default.
• W2066027939 cites W1989400013 @default.
• W2066027939 cites W1992142989 @default.
• W2066027939 cites W1994042895 @default.
• W2066027939 cites W1999746084 @default.
• W2066027939 cites W2010395737 @default.
• W2066027939 cites W2013705793 @default.
• W2066027939 cites W2014473727 @default.
• W2066027939 cites W2016575029 @default.
• W2066027939 cites W2023268846 @default.
• W2066027939 cites W2028705859 @default.
• W2066027939 cites W2030827604 @default.
• W2066027939 cites W2031236369 @default.
• W2066027939 cites W2032952917 @default.
• W2066027939 cites W2033242795 @default.
• W2066027939 cites W2039619365 @default.
• W2066027939 cites W2040588681 @default.
• W2066027939 cites W2042895002 @default.
• W2066027939 cites W2044110964 @default.
• W2066027939 cites W2046006021 @default.
• W2066027939 cites W2053184316 @default.
• W2066027939 cites W2053649709 @default.
• W2066027939 cites W2054552572 @default.
• W2066027939 cites W2056100616 @default.
• W2066027939 cites W2062406681 @default.
• W2066027939 cites W2064703428 @default.
• W2066027939 cites W2065726682 @default.
• W2066027939 cites W2071728536 @default.
• W2066027939 cites W2082755707 @default.
• W2066027939 cites W2085080193 @default.
• W2066027939 cites W2105086774 @default.
• W2066027939 cites W2111405228 @default.
• W2066027939 cites W2112983608 @default.
• W2066027939 cites W2117989916 @default.
• W2066027939 cites W2119130825 @default.
• W2066027939 cites W2137350608 @default.
• W2066027939 cites W2138152051 @default.
• W2066027939 cites W2138903446 @default.
• W2066027939 cites W2142850882 @default.
• W2066027939 cites W2146394305 @default.
• W2066027939 cites W2150936467 @default.
• W2066027939 cites W2151400960 @default.
• W2066027939 cites W2152710104 @default.
• W2066027939 cites W2162440323 @default.
• W2066027939 cites W2165169236 @default.
• W2066027939 cites W2169930621 @default.
• W2066027939 cites W2170380264 @default.
• W2066027939 cites W4243038715 @default.
• W2066027939 doi "https://doi.org/10.1523/jneurosci.2723-06.2006" @default.
• W2066027939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6674454" @default.
• W2066027939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16988041" @default.
• W2066027939 hasPublicationYear "2006" @default.
• W2066027939 type Work @default.
• W2066027939 sameAs 2066027939 @default.
• W2066027939 citedByCount "418" @default.
• W2066027939 countsByYear W20660279392012 @default.
• W2066027939 countsByYear W20660279392013 @default.
• W2066027939 countsByYear W20660279392014 @default.
• W2066027939 countsByYear W20660279392015 @default.
• W2066027939 countsByYear W20660279392016 @default.
• W2066027939 countsByYear W20660279392017 @default.
• W2066027939 countsByYear W20660279392018 @default.
• W2066027939 countsByYear W20660279392019 @default.
• W2066027939 countsByYear W20660279392020 @default.
• W2066027939 countsByYear W20660279392021 @default.
• W2066027939 countsByYear W20660279392022 @default.
• W2066027939 countsByYear W20660279392023 @default.
• W2066027939 crossrefType "journal-article" @default.
• W2066027939 hasAuthorship W2066027939A5009107221 @default.
• W2066027939 hasAuthorship W2066027939A5012111660 @default.
• W2066027939 hasAuthorship W2066027939A5046090769 @default.
• W2066027939 hasAuthorship W2066027939A5046983952 @default.
• W2066027939 hasAuthorship W2066027939A5047651170 @default.
• W2066027939 hasAuthorship W2066027939A5066365730 @default.
• W2066027939 hasAuthorship W2066027939A5077289778 @default.
• W2066027939 hasAuthorship W2066027939A5086175851 @default.
• W2066027939 hasBestOaLocation W20660279391 @default.
• W2066027939 hasConcept C126322002 @default.
• W2066027939 hasConcept C134018914 @default.

• next