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• W2066032237 abstract "Nearly without exception, the operations were performed with the declared purpose to sever sensory, pain-conveying, afferent nervous pathways, and without realization of the fact that (except in the case of exclusive section of the posterior roots), the norepinephrine-discharging, pain-producing efferent sympathetic fibers3 were, likewise, interrupted. In animal experiments, it has been shown that electrical stimulation of the cardiac sympathetic nerves is followed by an accumulation of catecholamines,4.s especially of norepinephrine,’ in the myocardium, whereas the cardiac catecholamine stores are largely depleted by sympathectomy.7” In view of these experimental findings, it appeared of interest to study the effect of sympathetic denervation on the function of the normal human heart by means of the “chronodynogram,” i.e. graphic measurement of the lengths of the isometric and isotonic contraction periods of the left ventricle (method of Blumberger) .‘#{176}Using the second standard lead of the electrocardiogram, the phonocardiogram over the upper sternum, and registration of the carotid pulse wave on the neck by means of a multi-channel apparatus, the length of the total systole of the left ventricle (Q or beginning of R wave to first vibration of second heart sound) is measured and expressed in thousandths of a second (paper speed 10 cm. per second). From this dimension, the length of the isotonic or ejection period (point of steep ascent of the carotid pulse wave to bottom of its incisura) is subtracted. The difference indicates the length of the isometric period. The isotonic period is of no particular significance, as far as the problem of neurovegetative effects on the heart muscle is concerned, but the isometric or tension period (TP) is characteristically shortened by adrenergic and lengthened by cholinergic influences.” Accordingly, this *This study was aided by grants from the U. S. Public Health Service, National Heart" @default.
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• W2066032237 date "1960-10-01" @default.
• W2066032237 modified "2023-09-27" @default.
• W2066032237 title "Effect of Transthoracic Endoscopic Sympathectomy on the Cardiac Neurovegetative Equilibrium and on Angina Pectoris" @default.
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• W2066032237 doi "https://doi.org/10.1378/chest.38.4.423" @default.
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