FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066034304> ?p ?o ?g. }

• W2066034304 endingPage "e1001832" @default.
• W2066034304 startingPage "e1001832" @default.
• W2066034304 abstract "Several studies have suggested crosstalk between different clathrin-independent endocytic pathways. However, the molecular mechanisms and functional relevance of these interactions are unclear. Caveolins and cavins are crucial components of caveolae, specialized microdomains that also constitute an endocytic route. Here we show that specific caveolar proteins are independently acting negative regulators of clathrin-independent endocytosis. Cavin-1 and Cavin-3, but not Cavin-2 or Cavin-4, are potent inhibitors of the clathrin-independent carriers/GPI-AP enriched early endosomal compartment (CLIC/GEEC) endocytic pathway, in a process independent of caveola formation. Caveolin-1 (CAV1) and CAV3 also inhibit the CLIC/GEEC pathway upon over-expression. Expression of caveolar protein leads to reduction in formation of early CLIC/GEEC carriers, as detected by quantitative electron microscopy analysis. Furthermore, the CLIC/GEEC pathway is upregulated in cells lacking CAV1/Cavin-1 or with reduced expression of Cavin-1 and Cavin-3. Inhibition by caveolins can be mimicked by the isolated caveolin scaffolding domain and is associated with perturbed diffusion of lipid microdomain components, as revealed by fluorescence recovery after photobleaching (FRAP) studies. In the absence of cavins (and caveolae) CAV1 is itself endocytosed preferentially through the CLIC/GEEC pathway, but the pathway loses polarization and sorting attributes with consequences for membrane dynamics and endocytic polarization in migrating cells and adult muscle tissue. We also found that noncaveolar Cavin-1 can act as a modulator for the activity of the key regulator of the CLIC/GEEC pathway, Cdc42. This work provides new insights into the regulation of noncaveolar clathrin-independent endocytosis by specific caveolar proteins, illustrating multiple levels of crosstalk between these pathways. We show for the first time a role for specific cavins in regulating the CLIC/GEEC pathway, provide a new tool to study this pathway, identify caveola-independent functions of the cavins and propose a novel mechanism for inhibition of the CLIC/GEEC pathway by caveolin." @default.
• W2066034304 created "2016-06-24" @default.
• W2066034304 creator A5006949339 @default.
• W2066034304 creator A5008963986 @default.
• W2066034304 creator A5012206249 @default.
• W2066034304 creator A5012291321 @default.
• W2066034304 creator A5024443532 @default.
• W2066034304 creator A5024813485 @default.
• W2066034304 creator A5029211283 @default.
• W2066034304 creator A5030586732 @default.
• W2066034304 creator A5032960507 @default.
• W2066034304 creator A5070498464 @default.
• W2066034304 creator A5082926542 @default.
• W2066034304 date "2014-04-08" @default.
• W2066034304 modified "2023-10-10" @default.
• W2066034304 title "Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis" @default.
• W2066034304 cites W1517168785 @default.
• W2066034304 cites W1821834469 @default.
• W2066034304 cites W1963556560 @default.
• W2066034304 cites W1963952319 @default.
• W2066034304 cites W1974158357 @default.
• W2066034304 cites W1974531816 @default.
• W2066034304 cites W1974586979 @default.
• W2066034304 cites W1979178282 @default.
• W2066034304 cites W1981861833 @default.
• W2066034304 cites W1982014179 @default.
• W2066034304 cites W1983771987 @default.
• W2066034304 cites W1986847123 @default.
• W2066034304 cites W1994537832 @default.
• W2066034304 cites W1997362992 @default.
• W2066034304 cites W2000638372 @default.
• W2066034304 cites W2001674490 @default.
• W2066034304 cites W2002594335 @default.
• W2066034304 cites W2004575760 @default.
• W2066034304 cites W2007124357 @default.
• W2066034304 cites W2011395933 @default.
• W2066034304 cites W2012810176 @default.
• W2066034304 cites W2014261553 @default.
• W2066034304 cites W2015704490 @default.
• W2066034304 cites W2020764743 @default.
• W2066034304 cites W2030727312 @default.
• W2066034304 cites W2032470185 @default.
• W2066034304 cites W2032661725 @default.
• W2066034304 cites W2039242651 @default.
• W2066034304 cites W2048592427 @default.
• W2066034304 cites W2050179335 @default.
• W2066034304 cites W2060073882 @default.
• W2066034304 cites W2060233546 @default.
• W2066034304 cites W2060669063 @default.
• W2066034304 cites W2069981183 @default.
• W2066034304 cites W2075796682 @default.
• W2066034304 cites W2080989887 @default.
• W2066034304 cites W2081225557 @default.
• W2066034304 cites W2081951738 @default.
• W2066034304 cites W2083227455 @default.
• W2066034304 cites W2099280999 @default.
• W2066034304 cites W2101149973 @default.
• W2066034304 cites W2103828505 @default.
• W2066034304 cites W2110169410 @default.
• W2066034304 cites W2110368797 @default.
• W2066034304 cites W2110581720 @default.
• W2066034304 cites W2117700932 @default.
• W2066034304 cites W2119176639 @default.
• W2066034304 cites W2124317881 @default.
• W2066034304 cites W2129123695 @default.
• W2066034304 cites W2131131437 @default.
• W2066034304 cites W2132854782 @default.
• W2066034304 cites W2132869487 @default.
• W2066034304 cites W2133327762 @default.
• W2066034304 cites W2135404068 @default.
• W2066034304 cites W2137960852 @default.
• W2066034304 cites W2140456056 @default.
• W2066034304 cites W2143254953 @default.
• W2066034304 cites W2146966728 @default.
• W2066034304 cites W2148400810 @default.
• W2066034304 cites W2151888693 @default.
• W2066034304 cites W2153767710 @default.
• W2066034304 cites W2153776880 @default.
• W2066034304 cites W2157963288 @default.
• W2066034304 cites W2160670356 @default.
• W2066034304 cites W2161591620 @default.
• W2066034304 cites W2161703993 @default.
• W2066034304 cites W2162451799 @default.
• W2066034304 cites W2167869386 @default.
• W2066034304 cites W2169364099 @default.
• W2066034304 cites W2187733050 @default.
• W2066034304 doi "https://doi.org/10.1371/journal.pbio.1001832" @default.
• W2066034304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3979662" @default.
• W2066034304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24714042" @default.
• W2066034304 hasPublicationYear "2014" @default.
• W2066034304 type Work @default.
• W2066034304 sameAs 2066034304 @default.
• W2066034304 citedByCount "125" @default.
• W2066034304 countsByYear W20660343042014 @default.
• W2066034304 countsByYear W20660343042015 @default.
• W2066034304 countsByYear W20660343042016 @default.
• W2066034304 countsByYear W20660343042017 @default.
• W2066034304 countsByYear W20660343042018 @default.

• next