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- W2066039142 abstract "After differential centrifugation 24 per cent of the total MAO activity of rat liver homogenates and 42 per cent of that in vas deferens was recovered in a microsomal fraction, the remainder being recovered in a mitochondrial pellet. The distribution of enzyme activities known to be associated with the outer membranes of mitochondria (kynurenine hydroxylase and NADH2-cytochrome c reductase) was similar to that of MAO, but succinic dehydrogenase activity was almost entirely mitochondrial. When vas deferens homogenates were subjected to density gradient centrifugation, a small particle fraction containing MAO and NADH2-cytochrome c reductase activities could be clearly separated from a fraction containing noradrenaline storage particles. It is concluded that MAO activity is not specifically associated with noradrenaline storage particles, and that the MAO activity recovered in microsomal fractions may arise as an artefact when mitochondria are disrupted during tissue homogenization." @default.
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- W2066039142 date "1968-08-01" @default.
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- W2066039142 title "Subcellular distribution of monoamine oxidase activity in rat liver and vas deferens" @default.
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- W2066039142 doi "https://doi.org/10.1016/0006-2952(68)90223-2" @default.
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