FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W206604037> ?p ?o ?g. }

• W206604037 endingPage "236" @default.
• W206604037 startingPage "223" @default.
• W206604037 abstract "This study describes various elements of the mechanism controlling norepinephrine (NE)-mediated release of serotonin (5HT) from rat pineal glands. After radiolabelling the endogenous pool of pineal 5HT with 3H-5HT, individual pineal glands were exposed to depolarizing buffers or those containing NE. Although 3H-5HT was not released by 50mM potassium, efflux of the indoleamine was increased by NE. Alpha-adrenergic receptors mediate the effects of NE as indicated by the fact that phenylephrine but not isoproterenol, a beta receptor agonist, also enhanced 3H-5HT release. This hypothesis is supported further by the fact that prazosin and phentolamine (alpha-antagonists) but not sotolal (beta-antagonist), inhibited the stimulatory effects of NE on 5HT release. In order to determine the intracellular second messenger involved in the 5HT release process, pineals were incubated with 8-bromo cAMP or the phorbol ester, PMA. PMA simulated the effects of NE and phenylephrine on 3H-5HT efflux, while cAMP had no effect. Furthermore, calcium-, phospholipid-dependent protein kinase activities in pineal homogenates were responsive to NE. These findings suggest that 5HT secretion from rat pinealocytes occurs rapidly in response to NE signals that act through alpha-adrenergic receptors in concert with phospholipid dependent protein kinase(s). These molecular processes are different from those involved in melatonin metabolism and may represent a general mechanism for regulating 5HT release in the brain." @default.
• W206604037 created "2016-06-24" @default.
• W206604037 creator A5033554249 @default.
• W206604037 creator A5076442934 @default.
• W206604037 date "1987-01-01" @default.
• W206604037 modified "2023-10-16" @default.
• W206604037 title "Molecular Mechanisms Controlling Norepinephrine-Mediated Release of Serotonin from Rat Pineal Glands" @default.
• W206604037 cites W1965064275 @default.
• W206604037 cites W1965742594 @default.
• W206604037 cites W1966097993 @default.
• W206604037 cites W1967433475 @default.
• W206604037 cites W1972004265 @default.
• W206604037 cites W1973673526 @default.
• W206604037 cites W1977060064 @default.
• W206604037 cites W1987170378 @default.
• W206604037 cites W1990082840 @default.
• W206604037 cites W1991413576 @default.
• W206604037 cites W1994664645 @default.
• W206604037 cites W1994743451 @default.
• W206604037 cites W1997290852 @default.
• W206604037 cites W1999911998 @default.
• W206604037 cites W2003532302 @default.
• W206604037 cites W2006444223 @default.
• W206604037 cites W2013680238 @default.
• W206604037 cites W2024686619 @default.
• W206604037 cites W2028212576 @default.
• W206604037 cites W2029818676 @default.
• W206604037 cites W2040163832 @default.
• W206604037 cites W2041766692 @default.
• W206604037 cites W2045246086 @default.
• W206604037 cites W2054478517 @default.
• W206604037 cites W2057728024 @default.
• W206604037 cites W2065786096 @default.
• W206604037 cites W2069304236 @default.
• W206604037 cites W2074282546 @default.
• W206604037 cites W2079059419 @default.
• W206604037 cites W2089459523 @default.
• W206604037 cites W2094654195 @default.
• W206604037 cites W2109390635 @default.
• W206604037 cites W2326675894 @default.
• W206604037 doi "https://doi.org/10.1007/978-1-4684-7618-7_17" @default.
• W206604037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2829582" @default.
• W206604037 hasPublicationYear "1987" @default.
• W206604037 type Work @default.
• W206604037 sameAs 206604037 @default.
• W206604037 citedByCount "5" @default.
• W206604037 countsByYear W2066040372021 @default.
• W206604037 crossrefType "book-chapter" @default.
• W206604037 hasAuthorship W206604037A5033554249 @default.
• W206604037 hasAuthorship W206604037A5076442934 @default.
• W206604037 hasConcept C126322002 @default.
• W206604037 hasConcept C134018914 @default.
• W206604037 hasConcept C170493617 @default.
• W206604037 hasConcept C185592680 @default.
• W206604037 hasConcept C202023056 @default.
• W206604037 hasConcept C2775864247 @default.
• W206604037 hasConcept C2776885963 @default.
• W206604037 hasConcept C2777952589 @default.
• W206604037 hasConcept C2778182776 @default.
• W206604037 hasConcept C2778938600 @default.
• W206604037 hasConcept C2780059843 @default.
• W206604037 hasConcept C2780648677 @default.
• W206604037 hasConcept C53910766 @default.
• W206604037 hasConcept C71924100 @default.
• W206604037 hasConcept C84393581 @default.
• W206604037 hasConcept C86803240 @default.
• W206604037 hasConceptScore W206604037C126322002 @default.
• W206604037 hasConceptScore W206604037C134018914 @default.
• W206604037 hasConceptScore W206604037C170493617 @default.
• W206604037 hasConceptScore W206604037C185592680 @default.
• W206604037 hasConceptScore W206604037C202023056 @default.
• W206604037 hasConceptScore W206604037C2775864247 @default.
• W206604037 hasConceptScore W206604037C2776885963 @default.
• W206604037 hasConceptScore W206604037C2777952589 @default.
• W206604037 hasConceptScore W206604037C2778182776 @default.
• W206604037 hasConceptScore W206604037C2778938600 @default.
• W206604037 hasConceptScore W206604037C2780059843 @default.
• W206604037 hasConceptScore W206604037C2780648677 @default.
• W206604037 hasConceptScore W206604037C53910766 @default.
• W206604037 hasConceptScore W206604037C71924100 @default.
• W206604037 hasConceptScore W206604037C84393581 @default.
• W206604037 hasConceptScore W206604037C86803240 @default.
• W206604037 hasLocation W2066040371 @default.
• W206604037 hasLocation W2066040372 @default.
• W206604037 hasOpenAccess W206604037 @default.
• W206604037 hasPrimaryLocation W2066040371 @default.
• W206604037 hasRelatedWork W1980447640 @default.
• W206604037 hasRelatedWork W2009768124 @default.
• W206604037 hasRelatedWork W2017589268 @default.
• W206604037 hasRelatedWork W2017830665 @default.
• W206604037 hasRelatedWork W2022103158 @default.
• W206604037 hasRelatedWork W2030382213 @default.
• W206604037 hasRelatedWork W2065221487 @default.
• W206604037 hasRelatedWork W206604037 @default.
• W206604037 hasRelatedWork W2075463443 @default.
• W206604037 hasRelatedWork W2082131896 @default.
• W206604037 isParatext "false" @default.
• W206604037 isRetracted "false" @default.

• next