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• W2066041199 abstract "MHC II-restricted antigen presentation typically results in recognition of exogenous foreign peptides by T lymphocytes and the subsequent generation of a cellular immune response. It is well known that the intracellular events involved in the assembly of peptide–MHC II complexes occur in the endocytic pathway. However, a point not often considered by immunologists is that the nature of these events suggests contradictions between the fundamental characteristics of the endocytic pathway as defined in non-specialized cells and those features necessary to facilitate efficient MHC II antigen processing in antigen-presenting cells. We believe that one reason why dendritic cells are so efficient at T-cell stimulation is their ability to reconcile these contradictions by regulating the activities and dynamics of their otherwise ‘normal’ complement of endocytic organelles. MHC II-restricted antigen presentation typically results in recognition of exogenous foreign peptides by T lymphocytes and the subsequent generation of a cellular immune response. It is well known that the intracellular events involved in the assembly of peptide–MHC II complexes occur in the endocytic pathway. However, a point not often considered by immunologists is that the nature of these events suggests contradictions between the fundamental characteristics of the endocytic pathway as defined in non-specialized cells and those features necessary to facilitate efficient MHC II antigen processing in antigen-presenting cells. We believe that one reason why dendritic cells are so efficient at T-cell stimulation is their ability to reconcile these contradictions by regulating the activities and dynamics of their otherwise ‘normal’ complement of endocytic organelles." @default.
• W2066041199 created "2016-06-24" @default.
• W2066041199 creator A5032873521 @default.
• W2066041199 creator A5085574965 @default.
• W2066041199 date "2005-02-01" @default.
• W2066041199 modified "2023-09-23" @default.
• W2066041199 title "Old lysosomes, new tricks: MHC II dynamics in DCs" @default.
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• W2066041199 doi "https://doi.org/10.1016/j.it.2004.11.008" @default.
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