Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066060295> ?p ?o ?g. }
- W2066060295 endingPage "204" @default.
- W2066060295 startingPage "196" @default.
- W2066060295 abstract "Rational drug design based on molecular targets is starting to revolutionize cancer care. To maximize its potential for patients, a concomitant leveraging of molecular knowledge for selection of patients to future and current therapeutic options is paramount. The terms “individualized”, “personalized”, or “precision therapy” are currently used to describe these efforts. Here, we summarize current knowledge for selection of systemic targeted and cytotoxic therapy for patients with non-small-cell lung cancer. Based on this knowledge, we present a potential decision algorithm to best select patients for currently available therapies, which include the treatment options single-agent erlotinib or gefitinib, the ALK inhibitor crizotinib, double agent gemcitabine and platinum, double agent platinum and pemetrexed, and as a default option a taxane combined with a non-platinum drug, for instance a vinca alkaloid. The addition of bevacizumab to double-agent chemotherapy is also discussed. Currently available data on predictive biomarkers are largely based on subgroup or companion biomarker analyses of patient cohorts or clinical trials. Current and emerging markers must be incorporated prospectively into the design of clinical trials that test novel and established agents to better understand their clinical utility and to refine selection parameters and marker interactions. Future development will lead to increasing complexity in clinical decision making with substantial anticipated benefits to patients including increased therapeutic efficacy, reduced toxicity, and better quality of life." @default.
- W2066060295 created "2016-06-24" @default.
- W2066060295 creator A5000445673 @default.
- W2066060295 creator A5001557696 @default.
- W2066060295 creator A5011247340 @default.
- W2066060295 creator A5017584174 @default.
- W2066060295 creator A5025836672 @default.
- W2066060295 creator A5027310894 @default.
- W2066060295 date "2010-12-01" @default.
- W2066060295 modified "2023-09-25" @default.
- W2066060295 title "Parameters for individualizing systemic therapy in non-small cell lung cancer" @default.
- W2066060295 cites W1749876465 @default.
- W2066060295 cites W1860205630 @default.
- W2066060295 cites W1879998198 @default.
- W2066060295 cites W1881540319 @default.
- W2066060295 cites W1964171037 @default.
- W2066060295 cites W1965316338 @default.
- W2066060295 cites W1969663349 @default.
- W2066060295 cites W1985329793 @default.
- W2066060295 cites W1989414440 @default.
- W2066060295 cites W1993446755 @default.
- W2066060295 cites W2001993057 @default.
- W2066060295 cites W2003721745 @default.
- W2066060295 cites W2004718750 @default.
- W2066060295 cites W2005599761 @default.
- W2066060295 cites W2012945281 @default.
- W2066060295 cites W2016710415 @default.
- W2066060295 cites W2027107867 @default.
- W2066060295 cites W2027640690 @default.
- W2066060295 cites W2029877928 @default.
- W2066060295 cites W2032861637 @default.
- W2066060295 cites W2037405647 @default.
- W2066060295 cites W2043696829 @default.
- W2066060295 cites W2043939793 @default.
- W2066060295 cites W2047770640 @default.
- W2066060295 cites W2048733384 @default.
- W2066060295 cites W2050368996 @default.
- W2066060295 cites W2055402151 @default.
- W2066060295 cites W2082592896 @default.
- W2066060295 cites W2083189837 @default.
- W2066060295 cites W2086955530 @default.
- W2066060295 cites W2087513914 @default.
- W2066060295 cites W2094764337 @default.
- W2066060295 cites W2095618958 @default.
- W2066060295 cites W2098514397 @default.
- W2066060295 cites W2099725888 @default.
- W2066060295 cites W2100785570 @default.
- W2066060295 cites W2100912832 @default.
- W2066060295 cites W2101329867 @default.
- W2066060295 cites W2104748005 @default.
- W2066060295 cites W2105026490 @default.
- W2066060295 cites W2105202429 @default.
- W2066060295 cites W2107183277 @default.
- W2066060295 cites W2107515803 @default.
- W2066060295 cites W2107565528 @default.
- W2066060295 cites W2109465247 @default.
- W2066060295 cites W2111710483 @default.
- W2066060295 cites W2112503651 @default.
- W2066060295 cites W2112621029 @default.
- W2066060295 cites W2117994949 @default.
- W2066060295 cites W2118004874 @default.
- W2066060295 cites W2119340070 @default.
- W2066060295 cites W2121110745 @default.
- W2066060295 cites W2129360604 @default.
- W2066060295 cites W2131687087 @default.
- W2066060295 cites W2132157071 @default.
- W2066060295 cites W2133867160 @default.
- W2066060295 cites W2134667653 @default.
- W2066060295 cites W2135836212 @default.
- W2066060295 cites W2136644329 @default.
- W2066060295 cites W2139939379 @default.
- W2066060295 cites W2141236760 @default.
- W2066060295 cites W2142460765 @default.
- W2066060295 cites W2145835533 @default.
- W2066060295 cites W2146147508 @default.
- W2066060295 cites W2150358925 @default.
- W2066060295 cites W2159711942 @default.
- W2066060295 cites W2161082953 @default.
- W2066060295 cites W2161769699 @default.
- W2066060295 cites W2161821474 @default.
- W2066060295 cites W2164529446 @default.
- W2066060295 cites W2166084034 @default.
- W2066060295 cites W2167798736 @default.
- W2066060295 cites W2237115187 @default.
- W2066060295 cites W2248853802 @default.
- W2066060295 cites W2250055160 @default.
- W2066060295 cites W2267882175 @default.
- W2066060295 cites W2320302422 @default.
- W2066060295 cites W2390326743 @default.
- W2066060295 cites W2589957652 @default.
- W2066060295 cites W4231971187 @default.
- W2066060295 cites W4243565663 @default.
- W2066060295 doi "https://doi.org/10.1016/j.drup.2010.10.001" @default.
- W2066060295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3865930" @default.
- W2066060295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21051275" @default.
- W2066060295 hasPublicationYear "2010" @default.
- W2066060295 type Work @default.
- W2066060295 sameAs 2066060295 @default.