Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066081519> ?p ?o ?g. }
- W2066081519 abstract "Although it is clear that adrenergic nervous system control of cardiac function decreases with age and that the effector organ fails to adjust to this decreased control, it is not completely evident which of the many mechanisms operant at the adrenergic-cardiac neuroeffector junction contribute to this state. Prejunctionally, it appears that norepinephrine content decreases with age and that adrenergic axonal degeneration occurs. Also, evidence is available to suggest that modulation by prejunctional alpha adrenergic receptors of norepinephrine release is altered with increasing age, as is neuronal uptake of norepinephrine. Postjunctionally, it appears that beta-adrenergic receptor sensitivity to agonists undergoes age-related alterations, and possibly post receptor mechanisms involved in receptor-response coupling. Other mechanisms, such as those involved in transmitter uptake into extraneuronal sites, adrenergic neuronal responsiveness to stimulation, transmitter release and turnover, calcium and prejunctional receptor modulation of transmitter release, postjunctional receptor development of supersensitivity or subsensitivity, need further elucidation in order to have an understanding of the factors that contribute to the breakdown of homeostatic mechanisms that regulate the heart." @default.
- W2066081519 created "2016-06-24" @default.
- W2066081519 creator A5011017516 @default.
- W2066081519 creator A5013378998 @default.
- W2066081519 creator A5041572555 @default.
- W2066081519 date "1984-12-01" @default.
- W2066081519 modified "2023-09-27" @default.
- W2066081519 title "Effects of age on the adrenergic cardiac neuroeffector junction" @default.
- W2066081519 cites W1581202897 @default.
- W2066081519 cites W1965214006 @default.
- W2066081519 cites W1972066297 @default.
- W2066081519 cites W1973280875 @default.
- W2066081519 cites W1975200068 @default.
- W2066081519 cites W1976537720 @default.
- W2066081519 cites W1977351097 @default.
- W2066081519 cites W1988625353 @default.
- W2066081519 cites W1990625147 @default.
- W2066081519 cites W1998265744 @default.
- W2066081519 cites W2000532115 @default.
- W2066081519 cites W2001428635 @default.
- W2066081519 cites W2007862505 @default.
- W2066081519 cites W2012726555 @default.
- W2066081519 cites W2019480281 @default.
- W2066081519 cites W2019959771 @default.
- W2066081519 cites W2029820220 @default.
- W2066081519 cites W2037707152 @default.
- W2066081519 cites W2038809010 @default.
- W2066081519 cites W2039684850 @default.
- W2066081519 cites W2042833340 @default.
- W2066081519 cites W2049355310 @default.
- W2066081519 cites W2049921498 @default.
- W2066081519 cites W2058921129 @default.
- W2066081519 cites W2062138944 @default.
- W2066081519 cites W2063373458 @default.
- W2066081519 cites W2070260046 @default.
- W2066081519 cites W2078256286 @default.
- W2066081519 cites W2079549564 @default.
- W2066081519 cites W2082607039 @default.
- W2066081519 cites W2083257957 @default.
- W2066081519 cites W2087516244 @default.
- W2066081519 cites W2093277140 @default.
- W2066081519 cites W2101285485 @default.
- W2066081519 cites W2103813535 @default.
- W2066081519 cites W2105224505 @default.
- W2066081519 cites W2108094183 @default.
- W2066081519 cites W2116732952 @default.
- W2066081519 cites W2126904140 @default.
- W2066081519 cites W2142803711 @default.
- W2066081519 cites W2150751984 @default.
- W2066081519 cites W2225473745 @default.
- W2066081519 cites W2255024424 @default.
- W2066081519 cites W2312531471 @default.
- W2066081519 cites W2316495338 @default.
- W2066081519 cites W2321993038 @default.
- W2066081519 cites W2327384329 @default.
- W2066081519 cites W2330724972 @default.
- W2066081519 cites W2333216046 @default.
- W2066081519 cites W2335458416 @default.
- W2066081519 cites W2432003513 @default.
- W2066081519 cites W421042709 @default.
- W2066081519 cites W1954071196 @default.
- W2066081519 doi "https://doi.org/10.1016/0024-3205(84)90025-0" @default.
- W2066081519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6513728" @default.
- W2066081519 hasPublicationYear "1984" @default.
- W2066081519 type Work @default.
- W2066081519 sameAs 2066081519 @default.
- W2066081519 citedByCount "12" @default.
- W2066081519 crossrefType "journal-article" @default.
- W2066081519 hasAuthorship W2066081519A5011017516 @default.
- W2066081519 hasAuthorship W2066081519A5013378998 @default.
- W2066081519 hasAuthorship W2066081519A5041572555 @default.
- W2066081519 hasConcept C126322002 @default.
- W2066081519 hasConcept C134018914 @default.
- W2066081519 hasConcept C158453852 @default.
- W2066081519 hasConcept C169760540 @default.
- W2066081519 hasConcept C170493617 @default.
- W2066081519 hasConcept C24998067 @default.
- W2066081519 hasConcept C2778514916 @default.
- W2066081519 hasConcept C2910296299 @default.
- W2066081519 hasConcept C40465926 @default.
- W2066081519 hasConcept C513476851 @default.
- W2066081519 hasConcept C71924100 @default.
- W2066081519 hasConcept C86803240 @default.
- W2066081519 hasConceptScore W2066081519C126322002 @default.
- W2066081519 hasConceptScore W2066081519C134018914 @default.
- W2066081519 hasConceptScore W2066081519C158453852 @default.
- W2066081519 hasConceptScore W2066081519C169760540 @default.
- W2066081519 hasConceptScore W2066081519C170493617 @default.
- W2066081519 hasConceptScore W2066081519C24998067 @default.
- W2066081519 hasConceptScore W2066081519C2778514916 @default.
- W2066081519 hasConceptScore W2066081519C2910296299 @default.
- W2066081519 hasConceptScore W2066081519C40465926 @default.
- W2066081519 hasConceptScore W2066081519C513476851 @default.
- W2066081519 hasConceptScore W2066081519C71924100 @default.
- W2066081519 hasConceptScore W2066081519C86803240 @default.
- W2066081519 hasLocation W20660815191 @default.
- W2066081519 hasLocation W20660815192 @default.
- W2066081519 hasOpenAccess W2066081519 @default.
- W2066081519 hasPrimaryLocation W20660815191 @default.
- W2066081519 hasRelatedWork W1974809200 @default.