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• W2066082439 abstract "<b><i>Background:</i></b> Basal cell carcinoma (BCC) is the most common type of skin cancer with an increasing incidence worldwide that imposes a considerable burden on public health. C-X-C chemokine receptor (CXCR4) plays a vital role in initiation, progression and metastasis of several types of cancers. The aim of the present study was to investigate the expression and clinical significance of CXCR4 in BCC. <b><i>Methods:</i></b> In this study, 80 samples of primary BCC were assessed for CXCR4 expression using immunohistochemistry. The mRNA and protein expression levels of CXCR4 were evaluated by real-time reverse transcription polymerase chain reaction and Western blot analysis, respectively. <b><i>Results:</i></b> CXCR4-positive staining was detected in 70% of BCC samples. Overexpression of CXCR4 was significantly associated with tumor size (>2 vs. 2 cm, p = 0.002) and pathological type (invasive vs. noninvasive, p = 0.007). CXCR4 was also upregulated at transcriptional and translational levels. <b><i>Conclusion:</i></b> Our study revealed that the expression of CXCR4 was associated with progression and invasion in patients with BCC. It may be a considerable biomarker to assess invasiveness of nasal-surface BCC and to guide clinical management of such tumors." @default.
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• W2066082439 date "2013-01-01" @default.
• W2066082439 modified "2023-09-23" @default.
• W2066082439 title "Expression of CXCR4 Is Associated with Progression and Invasion in Patients with Nasal-Surface Basal Cell Carcinoma" @default.
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• W2066082439 doi "https://doi.org/10.1159/000357027" @default.
• W2066082439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24401734" @default.
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