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- W2066086543 abstract "Eight L-alanine analogues of [des-Arg 9 ]-bradykinin and a few other compounds substituted in positions 5 and (or) 8 have been tested on rabbit aortic strips in order to identify the group(s) responsible for binding and (or) stimulation of the B 1 receptor. The results obtained with the L-Ala series have shown that the active group is located at the C-terminal end and it is probably Phe 8 , while the middle part and the N-terminal end of the peptide molecule are primarily involved in binding the agonist to the receptor. An aromatic ring is required in position 8 for activation of receptors, since the elimination of aromaticity (as in [Leu 8 ,des-Arg 9 ]-bradykinin and in [cyclohexylalanine 8 ,des-Arg 9 ]-bradykinin) brings about pure and competitive antagonists. Some compounds exert an angiotensin-iike effect when applied at very high concentrations." @default.
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- W2066086543 date "1979-06-01" @default.
- W2066086543 modified "2023-10-17" @default.
- W2066086543 title "Structure–activity studies of [des-Arg<sup>9</sup>]-bradykinin on the B<sub>1</sub> receptor of the rabbit aorta" @default.
- W2066086543 doi "https://doi.org/10.1139/y79-085" @default.
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