Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066114516> ?p ?o ?g. }
- W2066114516 endingPage "253" @default.
- W2066114516 startingPage "245" @default.
- W2066114516 abstract "A variety of second messenger systems have been implicated in the intracellular mechanisms of tolerance development to the analgesic actions of morphine, a mu opioid, and clonidine, an alpha-2 adrenergic receptor agonist. Here, we studied mice that carry a null mutation in the gene encoding a neuronal specific isoform of protein kinase C (PKC), namely, PKCγ. We used the tail-flick test to construct dose–response curves before and 4 days after chronic morphine (75-mg pellets, subcutaneously (s.c.)) or clonidine treatment (0.3 mg/kg, s.c., twice daily). Baseline tail-flick latencies did not differ in PKCγ mutant and wild-type mice (3–4 s). Both morphine and clonidine produced a dose-dependent suppression of the tail-flick response with an ED50 (effective dose resulting in a 50% reduction of the control response) value (2.0 mg/kg for morphine and 0.1 mg/kg for clonidine) that was similar for naive mutant and wild-type mice. In contrast, after 4 days of drug delivery, mutant mice showed significantly less rightward shift in the dose–response curve to morphine (six-fold for wild-type and three-fold for mutant mice) and to clonidine (five-fold for wild-type and no shift for the mutant mice). These results indicate that PKCγ contributes to the development of tolerance to the analgesic effects of both morphine and clonidine. Chronic morphine treatment can also result in sensitization of spinal cord neurons and increased pain behaviors following a noxious insult. To assess the contribution of PKCγ to this process, we studied the responses of wild-type and mutant mice to an intraplantar injection of formalin (a model of persistent pain) following chronic morphine treatment. Although morphine tolerance increased formalin-evoked persistent pain behavior and Fos-LI in wild-type mice, there was no difference between placebo- and morphine-treated mutant mice, suggesting that PKCγ also contributes to chronic morphine-induced changes in nociceptive processing." @default.
- W2066114516 created "2016-06-24" @default.
- W2066114516 creator A5007740596 @default.
- W2066114516 creator A5056195315 @default.
- W2066114516 creator A5084330525 @default.
- W2066114516 creator A5086350130 @default.
- W2066114516 date "2001-12-01" @default.
- W2066114516 modified "2023-10-14" @default.
- W2066114516 title "Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKCγ mutant mice" @default.
- W2066114516 cites W1655589213 @default.
- W2066114516 cites W1799894364 @default.
- W2066114516 cites W1942825033 @default.
- W2066114516 cites W1979293468 @default.
- W2066114516 cites W1979996083 @default.
- W2066114516 cites W1984010265 @default.
- W2066114516 cites W1988489044 @default.
- W2066114516 cites W1989585778 @default.
- W2066114516 cites W1993878963 @default.
- W2066114516 cites W1998126770 @default.
- W2066114516 cites W1999536978 @default.
- W2066114516 cites W2005656584 @default.
- W2066114516 cites W2007174401 @default.
- W2066114516 cites W2014909810 @default.
- W2066114516 cites W2020869636 @default.
- W2066114516 cites W2020876837 @default.
- W2066114516 cites W2031811175 @default.
- W2066114516 cites W2033525233 @default.
- W2066114516 cites W2042253951 @default.
- W2066114516 cites W2042544503 @default.
- W2066114516 cites W2046983320 @default.
- W2066114516 cites W2050445424 @default.
- W2066114516 cites W2050601812 @default.
- W2066114516 cites W2051473177 @default.
- W2066114516 cites W2059049376 @default.
- W2066114516 cites W2060966417 @default.
- W2066114516 cites W2070660603 @default.
- W2066114516 cites W2084043489 @default.
- W2066114516 cites W2086948258 @default.
- W2066114516 cites W2093368672 @default.
- W2066114516 cites W2094988830 @default.
- W2066114516 cites W2134911233 @default.
- W2066114516 cites W2143046795 @default.
- W2066114516 cites W2146958131 @default.
- W2066114516 cites W2165498557 @default.
- W2066114516 cites W2167262614 @default.
- W2066114516 cites W29671035 @default.
- W2066114516 doi "https://doi.org/10.1016/s0304-3959(01)00353-0" @default.
- W2066114516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11731061" @default.
- W2066114516 hasPublicationYear "2001" @default.
- W2066114516 type Work @default.
- W2066114516 sameAs 2066114516 @default.
- W2066114516 citedByCount "115" @default.
- W2066114516 countsByYear W20661145162012 @default.
- W2066114516 countsByYear W20661145162013 @default.
- W2066114516 countsByYear W20661145162014 @default.
- W2066114516 countsByYear W20661145162015 @default.
- W2066114516 countsByYear W20661145162016 @default.
- W2066114516 countsByYear W20661145162019 @default.
- W2066114516 countsByYear W20661145162020 @default.
- W2066114516 countsByYear W20661145162021 @default.
- W2066114516 countsByYear W20661145162022 @default.
- W2066114516 countsByYear W20661145162023 @default.
- W2066114516 crossrefType "journal-article" @default.
- W2066114516 hasAuthorship W2066114516A5007740596 @default.
- W2066114516 hasAuthorship W2066114516A5056195315 @default.
- W2066114516 hasAuthorship W2066114516A5084330525 @default.
- W2066114516 hasAuthorship W2066114516A5086350130 @default.
- W2066114516 hasConcept C126322002 @default.
- W2066114516 hasConcept C134018914 @default.
- W2066114516 hasConcept C170493617 @default.
- W2066114516 hasConcept C185592680 @default.
- W2066114516 hasConcept C195794163 @default.
- W2066114516 hasConcept C2777389121 @default.
- W2066114516 hasConcept C2778399450 @default.
- W2066114516 hasConcept C2778938600 @default.
- W2066114516 hasConcept C2780820201 @default.
- W2066114516 hasConcept C2781063702 @default.
- W2066114516 hasConcept C55493867 @default.
- W2066114516 hasConcept C62478195 @default.
- W2066114516 hasConcept C71924100 @default.
- W2066114516 hasConcept C98274493 @default.
- W2066114516 hasConceptScore W2066114516C126322002 @default.
- W2066114516 hasConceptScore W2066114516C134018914 @default.
- W2066114516 hasConceptScore W2066114516C170493617 @default.
- W2066114516 hasConceptScore W2066114516C185592680 @default.
- W2066114516 hasConceptScore W2066114516C195794163 @default.
- W2066114516 hasConceptScore W2066114516C2777389121 @default.
- W2066114516 hasConceptScore W2066114516C2778399450 @default.
- W2066114516 hasConceptScore W2066114516C2778938600 @default.
- W2066114516 hasConceptScore W2066114516C2780820201 @default.
- W2066114516 hasConceptScore W2066114516C2781063702 @default.
- W2066114516 hasConceptScore W2066114516C55493867 @default.
- W2066114516 hasConceptScore W2066114516C62478195 @default.
- W2066114516 hasConceptScore W2066114516C71924100 @default.
- W2066114516 hasConceptScore W2066114516C98274493 @default.
- W2066114516 hasIssue "3" @default.
- W2066114516 hasLocation W20661145161 @default.
- W2066114516 hasOpenAccess W2066114516 @default.