FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066115176> ?p ?o ?g. }

• W2066115176 endingPage "191" @default.
• W2066115176 startingPage "183" @default.
• W2066115176 abstract "The E2 enzyme, Ubc13, and the E2 enzyme variants, Uevs, form stable, high affinity complexes for the assembly of Lys63-linked ubiquitin chains. This process is involved in error-free DNA postreplication repair, the activation of kinases in the NF-kappaB signaling pathway and possibly other cellular processes. To further investigate the roles played by Ubc13 in a whole animal model, we report here the molecular cloning of mouse UBC13 and show for the first time that a mammalian UBC13 gene is able to complement the yeast ubc13 null mutant. Furthermore, in vitro analyses and a yeast two-hybrid assay show that mUbc13 is able to form stable complexes with various Uevs. In the presence of E1 and ATP, mUbc13 forms thiolesters with ubiquitin; however, the formation of Lys63-linked di-ubiquitin and multi-ubiquitin chains is dependent on Uevs. These results suggest that the roles of UBC13 are conserved throughout eukaryotes and that the mouse is an appropriate model for the study of Ubc13-mediated Lys63-linked ubiquitin signaling pathways in humans." @default.
• W2066115176 created "2016-06-24" @default.
• W2066115176 creator A5009806341 @default.
• W2066115176 creator A5039160053 @default.
• W2066115176 creator A5052203784 @default.
• W2066115176 creator A5054367035 @default.
• W2066115176 creator A5081730087 @default.
• W2066115176 date "2002-02-01" @default.
• W2066115176 modified "2023-09-23" @default.
• W2066115176 title "Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination" @default.
• W2066115176 cites W1480515133 @default.
• W2066115176 cites W1535363390 @default.
• W2066115176 cites W1553437553 @default.
• W2066115176 cites W1559083131 @default.
• W2066115176 cites W1566221754 @default.
• W2066115176 cites W1571547690 @default.
• W2066115176 cites W1600472471 @default.
• W2066115176 cites W1903900184 @default.
• W2066115176 cites W1965028987 @default.
• W2066115176 cites W1972469838 @default.
• W2066115176 cites W1981916517 @default.
• W2066115176 cites W1983441877 @default.
• W2066115176 cites W1988617344 @default.
• W2066115176 cites W1995310349 @default.
• W2066115176 cites W1996224026 @default.
• W2066115176 cites W2020294551 @default.
• W2066115176 cites W2021326140 @default.
• W2066115176 cites W2022148699 @default.
• W2066115176 cites W2037166985 @default.
• W2066115176 cites W2037454778 @default.
• W2066115176 cites W2061050157 @default.
• W2066115176 cites W2061580741 @default.
• W2066115176 cites W2067863011 @default.
• W2066115176 cites W2069403120 @default.
• W2066115176 cites W2075734864 @default.
• W2066115176 cites W2078709018 @default.
• W2066115176 cites W2093315580 @default.
• W2066115176 cites W2121781216 @default.
• W2066115176 cites W2127657018 @default.
• W2066115176 cites W2132024812 @default.
• W2066115176 cites W2136190630 @default.
• W2066115176 cites W2158824345 @default.
• W2066115176 cites W2328103491 @default.
• W2066115176 cites W4251683570 @default.
• W2066115176 doi "https://doi.org/10.1016/s0378-1119(02)00409-2" @default.
• W2066115176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12039045" @default.
• W2066115176 hasPublicationYear "2002" @default.
• W2066115176 type Work @default.
• W2066115176 sameAs 2066115176 @default.
• W2066115176 citedByCount "33" @default.
• W2066115176 countsByYear W20661151762012 @default.
• W2066115176 countsByYear W20661151762013 @default.
• W2066115176 countsByYear W20661151762014 @default.
• W2066115176 countsByYear W20661151762016 @default.
• W2066115176 countsByYear W20661151762017 @default.
• W2066115176 countsByYear W20661151762019 @default.
• W2066115176 countsByYear W20661151762021 @default.
• W2066115176 countsByYear W20661151762022 @default.
• W2066115176 crossrefType "journal-article" @default.
• W2066115176 hasAuthorship W2066115176A5009806341 @default.
• W2066115176 hasAuthorship W2066115176A5039160053 @default.
• W2066115176 hasAuthorship W2066115176A5052203784 @default.
• W2066115176 hasAuthorship W2066115176A5054367035 @default.
• W2066115176 hasAuthorship W2066115176A5081730087 @default.
• W2066115176 hasConcept C104317684 @default.
• W2066115176 hasConcept C134459356 @default.
• W2066115176 hasConcept C182561583 @default.
• W2066115176 hasConcept C25602115 @default.
• W2066115176 hasConcept C2777576037 @default.
• W2066115176 hasConcept C2779222958 @default.
• W2066115176 hasConcept C54355233 @default.
• W2066115176 hasConcept C552990157 @default.
• W2066115176 hasConcept C55493867 @default.
• W2066115176 hasConcept C86803240 @default.
• W2066115176 hasConcept C95444343 @default.
• W2066115176 hasConceptScore W2066115176C104317684 @default.
• W2066115176 hasConceptScore W2066115176C134459356 @default.
• W2066115176 hasConceptScore W2066115176C182561583 @default.
• W2066115176 hasConceptScore W2066115176C25602115 @default.
• W2066115176 hasConceptScore W2066115176C2777576037 @default.
• W2066115176 hasConceptScore W2066115176C2779222958 @default.
• W2066115176 hasConceptScore W2066115176C54355233 @default.
• W2066115176 hasConceptScore W2066115176C552990157 @default.
• W2066115176 hasConceptScore W2066115176C55493867 @default.
• W2066115176 hasConceptScore W2066115176C86803240 @default.
• W2066115176 hasConceptScore W2066115176C95444343 @default.
• W2066115176 hasIssue "1-2" @default.
• W2066115176 hasLocation W20661151761 @default.
• W2066115176 hasLocation W20661151762 @default.
• W2066115176 hasOpenAccess W2066115176 @default.
• W2066115176 hasPrimaryLocation W20661151761 @default.
• W2066115176 hasRelatedWork W1987982805 @default.
• W2066115176 hasRelatedWork W1999763554 @default.
• W2066115176 hasRelatedWork W2013007761 @default.
• W2066115176 hasRelatedWork W2041022871 @default.
• W2066115176 hasRelatedWork W2049686095 @default.
• W2066115176 hasRelatedWork W2060295565 @default.
• W2066115176 hasRelatedWork W2095693152 @default.

• next