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- W2066117733 abstract "<h3>To the Editor.—</h3> Howarth and Grace<sup>1</sup>have suggested that a number of reports indicate that tricyclic antidepressants (TCAs) might work effectively in the treatment of delusional depression, and they have cited three reports.<sup>2-4</sup>Our reading is that only the 1978 reanalysis by Quitkin et al<sup>2</sup>of Klein's 1959 data might suggest that delusional depressive patients respond to TCAs at a rate equal to that of nondelusional patients. The other two cited studies actually show a lower rate of response among delusional compared with nondelusional patients. The study by De Carolis et al<sup>3</sup>is particularly striking because of the sample size (181 delusional patients with a 40% response rate vs 256 nondelusional patients with a 68% response rate; P<.001). Simpson et al<sup>4</sup>clearly noted that depressed patients who were deluded tended to have a higher failure rate than those who were not deluded. Both studies' conclusions" @default.
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- W2066117733 date "1986-10-01" @default.
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- W2066117733 title "Delusional Depression: Tricyclic Response" @default.
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- W2066117733 doi "https://doi.org/10.1001/archpsyc.1986.01800100108016" @default.
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