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- W2066132332 abstract "Typical sets of specific activity versus time data arising from physiological experiments involving tracers are analyzed. Curves involving sums of exponential terms are fitted to these data and compared with fitted polynomial forms. Numerical techniques utilizing exponential forms and the principle of least squares were developed especially for this problem as described in an earlier paper1. These techniques have now been extended and applied to the results of human and animal experiments. Great care must be exercised in identifying the individually fitted parameters with physical constants. This is implied by the present study, and emphasized by a comparison of the statistical errors of the various fittings. Actual values of the fitted parameters are very sensitive to variations in the fitting technique. Values of functions derived from these parameters which have a physical interpretation, for example, the transfer rate of a chemical constituent into a biological compartment, are rather more stable under such variations. This is particularly true if the rates are found by extrapolation of fitted functions to the zero time of administration of the tracer to the system. However, calculated error bounds can sometimes be quite large. It would appear best to establish a uniform technique for running the experiments and analyzing the data and to consider as significant only differences between one group or subject and the next." @default.
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- W2066132332 date "1962-05-01" @default.
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- W2066132332 title "Selection of a numerical technique for analyzing experimental data of the decay type with special reference to the use of tracers in biological systems" @default.
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- W2066132332 doi "https://doi.org/10.1016/0006-3002(62)90694-7" @default.
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