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- W2066132912 abstract "To evaluate the effect of clomiphene citrate addition to gonadotropin releasing hormone (GnRH) antagonist protocols in poor responders undergoing assisted reproductive technology (ART). A prospective randomized controlled study was conducted on poor responders undergoing ART treatment in IVF Center of University of Tokyo Hospital. This study was approved by the Intutional Review Board. Among the patients who visited IVF Center of University of Tokyo Hospital for the purpose of ART, those who fitted at least one of the following inclusion criteria and who fitted no exclusion criteria were eligible for this study. Inclusion criteria: 1. elevated basal serum FSH levels (>10mIU/ml) 2. antral follicle counts <7 in early follicular phase 3. previous poor response to ART treatment (<5 retrieved oocytes) Exclusion criteria: 1.over the age of 45 2. those who underwent oocyte retrieval cycles more than 3 times The patients who gave a written informed consent form were allocated into two groups. In group 1 (n=44), controlled ovarian stimulation was initiated on day3 with 5 days of clomiphene citrate (2 tabs daily), followed by human menopausal gonadotropin (hMG) administration. After leading follicle diameter reached 14mm, GnRH antagonist Ganirelix was administered in addtion to hMG. In group 2 (n=45), hMG administration was started on day3, followed by combination with Ganirelix in the same way. There were no significant differences in estradiol levels on day of hCG, number of growing follicles, number of retrieved oocytes and fertilization rate between the two groups. In group 1, total hMG dose and cost for controlled ovarian stimulation were significantly less than those in group 2. Embryo transfer cancellation rate per oocyte retrieval was significantly higher in group 1 (28.6% vs. 2.5%), which was mainly due to inadequate endometrial preparation. However, live-birth rate per fresh embryo transfer and cumulative live-birth rate per patient in the two groups were comparable (9.1% vs. 11.1% and 20.5% vs. 17.8%, respectively). The addition of clomiphene citrate in GnRH antagonist protocols could not improve clinical outcomes of ART in poor responders, but it could reduce hMG dose and cost for controlled ovarian stimulation." @default.
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- W2066132912 date "2014-09-01" @default.
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- W2066132912 title "Efficacy of clomiphene citrate supplementation to conventional GnRH antagonist protocols in poor responders undergoing assisted reproductive technology - a prospective randomized trial" @default.
- W2066132912 doi "https://doi.org/10.1016/j.fertnstert.2014.07.224" @default.
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