Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066138261> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2066138261 abstract "Intravenous administration of heterologous anti-thymocyte antibodies, which react with rat mesangial cells, induced minimal mesangiolysis (6 hours to 3 days) followed by mesangial hypercellularity. Moreover, autologous immunoglobulins appeared in the mesangium within 1 or 2 weeks. At the same time, electron microscopy demonstrated mesangial deposits. Accompanying these pathological alterations, significant proteinuria developed. To accelerate an acute autologous immune reaction, rats were preimmunized with rabbit IgG prior to the injection of anti-thymocyte antibodies. They revealed marked mesangiolytic lesions 3 days after injection with deposition of autologous immunoglobulins and C 3 in the mesangium. In contrast, there was no significant proteinuria. Thus, mild pathological alterations in the mesangium induced by heterologous and subsequent autologous immune reactions caused proteinuria, and accelerated immune injury to the mesangium produced severe mesangiolysis without proteinuria. Based on these findings, it is suggested that the time-lapse between heterologous and autologous immune reactions to the mesangium influences the pathological alterations and clinical manifestations occurring in mesangial injury by anti-thymocyte antibody." @default.
- W2066138261 created "2016-06-24" @default.
- W2066138261 creator A5001299618 @default.
- W2066138261 creator A5002113575 @default.
- W2066138261 creator A5055796894 @default.
- W2066138261 creator A5080835756 @default.
- W2066138261 date "1993-05-01" @default.
- W2066138261 modified "2023-09-29" @default.
- W2066138261 title "Dissociation of Clinical Manifestation and Histopathology in the Course of Mesangial Injury by Anti-Thymocyte Antibody" @default.
- W2066138261 cites W12377914 @default.
- W2066138261 cites W1547325391 @default.
- W2066138261 cites W1993340476 @default.
- W2066138261 cites W1993851092 @default.
- W2066138261 cites W1994456027 @default.
- W2066138261 cites W2033465719 @default.
- W2066138261 cites W2043212350 @default.
- W2066138261 cites W2052996694 @default.
- W2066138261 cites W2062623244 @default.
- W2066138261 cites W2123278448 @default.
- W2066138261 cites W2143060667 @default.
- W2066138261 cites W2164620775 @default.
- W2066138261 cites W2402220221 @default.
- W2066138261 cites W2410564937 @default.
- W2066138261 doi "https://doi.org/10.1016/s0344-0338(11)80332-8" @default.
- W2066138261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8351246" @default.
- W2066138261 hasPublicationYear "1993" @default.
- W2066138261 type Work @default.
- W2066138261 sameAs 2066138261 @default.
- W2066138261 citedByCount "2" @default.
- W2066138261 crossrefType "journal-article" @default.
- W2066138261 hasAuthorship W2066138261A5001299618 @default.
- W2066138261 hasAuthorship W2066138261A5002113575 @default.
- W2066138261 hasAuthorship W2066138261A5055796894 @default.
- W2066138261 hasAuthorship W2066138261A5080835756 @default.
- W2066138261 hasConcept C104317684 @default.
- W2066138261 hasConcept C126322002 @default.
- W2066138261 hasConcept C142724271 @default.
- W2066138261 hasConcept C159654299 @default.
- W2066138261 hasConcept C185592680 @default.
- W2066138261 hasConcept C203014093 @default.
- W2066138261 hasConcept C2778474638 @default.
- W2066138261 hasConcept C2779937669 @default.
- W2066138261 hasConcept C2780091579 @default.
- W2066138261 hasConcept C2780115692 @default.
- W2066138261 hasConcept C2780368995 @default.
- W2066138261 hasConcept C2910125355 @default.
- W2066138261 hasConcept C55493867 @default.
- W2066138261 hasConcept C71924100 @default.
- W2066138261 hasConcept C8891405 @default.
- W2066138261 hasConceptScore W2066138261C104317684 @default.
- W2066138261 hasConceptScore W2066138261C126322002 @default.
- W2066138261 hasConceptScore W2066138261C142724271 @default.
- W2066138261 hasConceptScore W2066138261C159654299 @default.
- W2066138261 hasConceptScore W2066138261C185592680 @default.
- W2066138261 hasConceptScore W2066138261C203014093 @default.
- W2066138261 hasConceptScore W2066138261C2778474638 @default.
- W2066138261 hasConceptScore W2066138261C2779937669 @default.
- W2066138261 hasConceptScore W2066138261C2780091579 @default.
- W2066138261 hasConceptScore W2066138261C2780115692 @default.
- W2066138261 hasConceptScore W2066138261C2780368995 @default.
- W2066138261 hasConceptScore W2066138261C2910125355 @default.
- W2066138261 hasConceptScore W2066138261C55493867 @default.
- W2066138261 hasConceptScore W2066138261C71924100 @default.
- W2066138261 hasConceptScore W2066138261C8891405 @default.
- W2066138261 hasLocation W20661382611 @default.
- W2066138261 hasLocation W20661382612 @default.
- W2066138261 hasOpenAccess W2066138261 @default.
- W2066138261 hasPrimaryLocation W20661382611 @default.
- W2066138261 hasRelatedWork W1530910736 @default.
- W2066138261 hasRelatedWork W1969300951 @default.
- W2066138261 hasRelatedWork W1993773967 @default.
- W2066138261 hasRelatedWork W2001412071 @default.
- W2066138261 hasRelatedWork W2050973563 @default.
- W2066138261 hasRelatedWork W2055014406 @default.
- W2066138261 hasRelatedWork W2066138261 @default.
- W2066138261 hasRelatedWork W2084865399 @default.
- W2066138261 hasRelatedWork W2143543224 @default.
- W2066138261 hasRelatedWork W2272762607 @default.
- W2066138261 isParatext "false" @default.
- W2066138261 isRetracted "false" @default.
- W2066138261 magId "2066138261" @default.
- W2066138261 workType "article" @default.