Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066141010> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2066141010 abstract "We show that early indicators of osteoarthritis are observed in Raman spectroscopy by probing femur surfaces excisedfrom mouse models of early-onset osteoarthritis. Current clinical methods to examine arthritic joints include radiologicalexamination of the joint, but may not be capable of detecting subtle chemical changes in the bone tissue, which mayprovide the earliest indications of osteoarthritis. Recent research has indicated that the subchondral bone may have amore significant role in the onset of osteoarthritis than previously realized. We will report the effect of age and defectivetype II collagen on Raman band area ratios used to describe bone structure and function. The carbonate-to-phosphateratio is used to assess carbonate substitution into the bone mineral and the mineral-to-matrix ratio is used to measurebone mineralization. Mineral-to-matrix ratios indicate that subchondral bone becomes less mineralized as both thewild-type and Del1 (+/-) transgenic mice age. Moreover, the mineral-to-matrix ratios show that the subchondral bone ofDel1 (+/-) transgenic mice is less mineralized than that of the wild-type mice. Carbonate-to-phosphate ratios from Del1(+/-) transgenic mice follow the same longitudinal trend as wild-type mice. The ratio is slightly higher in the transgenicmice, indicating more carbonate content in the bone mineral. Raman characterization of bone mineralization provides aninvaluable insight into the process of cartilage degeneration and the relationship with subchondral bone at theultrastructural level." @default.
- W2066141010 created "2016-06-24" @default.
- W2066141010 creator A5007849105 @default.
- W2066141010 creator A5034548203 @default.
- W2066141010 creator A5088672352 @default.
- W2066141010 date "2007-02-08" @default.
- W2066141010 modified "2023-09-23" @default.
- W2066141010 title "Correlating chemical changes in subchondral bone mineral due to aging or defective type II collagen by Raman spectroscopy" @default.
- W2066141010 doi "https://doi.org/10.1117/12.701095" @default.
- W2066141010 hasPublicationYear "2007" @default.
- W2066141010 type Work @default.
- W2066141010 sameAs 2066141010 @default.
- W2066141010 citedByCount "3" @default.
- W2066141010 countsByYear W20661410102012 @default.
- W2066141010 countsByYear W20661410102015 @default.
- W2066141010 countsByYear W20661410102021 @default.
- W2066141010 crossrefType "proceedings-article" @default.
- W2066141010 hasAuthorship W2066141010A5007849105 @default.
- W2066141010 hasAuthorship W2066141010A5034548203 @default.
- W2066141010 hasAuthorship W2066141010A5088672352 @default.
- W2066141010 hasConcept C105702510 @default.
- W2066141010 hasConcept C106487976 @default.
- W2066141010 hasConcept C111696902 @default.
- W2066141010 hasConcept C120665830 @default.
- W2066141010 hasConcept C121332964 @default.
- W2066141010 hasConcept C12554922 @default.
- W2066141010 hasConcept C126322002 @default.
- W2066141010 hasConcept C142724271 @default.
- W2066141010 hasConcept C159985019 @default.
- W2066141010 hasConcept C178790620 @default.
- W2066141010 hasConcept C185592680 @default.
- W2066141010 hasConcept C192562407 @default.
- W2066141010 hasConcept C202751555 @default.
- W2066141010 hasConcept C204787440 @default.
- W2066141010 hasConcept C2776164576 @default.
- W2066141010 hasConcept C2776541429 @default.
- W2066141010 hasConcept C2776886416 @default.
- W2066141010 hasConcept C2778260815 @default.
- W2066141010 hasConcept C2780550940 @default.
- W2066141010 hasConcept C2780644872 @default.
- W2066141010 hasConcept C2993697008 @default.
- W2066141010 hasConcept C40003534 @default.
- W2066141010 hasConcept C537208039 @default.
- W2066141010 hasConcept C55493867 @default.
- W2066141010 hasConcept C71924100 @default.
- W2066141010 hasConcept C86803240 @default.
- W2066141010 hasConceptScore W2066141010C105702510 @default.
- W2066141010 hasConceptScore W2066141010C106487976 @default.
- W2066141010 hasConceptScore W2066141010C111696902 @default.
- W2066141010 hasConceptScore W2066141010C120665830 @default.
- W2066141010 hasConceptScore W2066141010C121332964 @default.
- W2066141010 hasConceptScore W2066141010C12554922 @default.
- W2066141010 hasConceptScore W2066141010C126322002 @default.
- W2066141010 hasConceptScore W2066141010C142724271 @default.
- W2066141010 hasConceptScore W2066141010C159985019 @default.
- W2066141010 hasConceptScore W2066141010C178790620 @default.
- W2066141010 hasConceptScore W2066141010C185592680 @default.
- W2066141010 hasConceptScore W2066141010C192562407 @default.
- W2066141010 hasConceptScore W2066141010C202751555 @default.
- W2066141010 hasConceptScore W2066141010C204787440 @default.
- W2066141010 hasConceptScore W2066141010C2776164576 @default.
- W2066141010 hasConceptScore W2066141010C2776541429 @default.
- W2066141010 hasConceptScore W2066141010C2776886416 @default.
- W2066141010 hasConceptScore W2066141010C2778260815 @default.
- W2066141010 hasConceptScore W2066141010C2780550940 @default.
- W2066141010 hasConceptScore W2066141010C2780644872 @default.
- W2066141010 hasConceptScore W2066141010C2993697008 @default.
- W2066141010 hasConceptScore W2066141010C40003534 @default.
- W2066141010 hasConceptScore W2066141010C537208039 @default.
- W2066141010 hasConceptScore W2066141010C55493867 @default.
- W2066141010 hasConceptScore W2066141010C71924100 @default.
- W2066141010 hasConceptScore W2066141010C86803240 @default.
- W2066141010 hasLocation W20661410101 @default.
- W2066141010 hasOpenAccess W2066141010 @default.
- W2066141010 hasPrimaryLocation W20661410101 @default.
- W2066141010 hasRelatedWork W1968679476 @default.
- W2066141010 hasRelatedWork W1986101966 @default.
- W2066141010 hasRelatedWork W2072303803 @default.
- W2066141010 hasRelatedWork W2152522044 @default.
- W2066141010 hasRelatedWork W2289258979 @default.
- W2066141010 hasRelatedWork W2332494926 @default.
- W2066141010 hasRelatedWork W2968874307 @default.
- W2066141010 hasRelatedWork W386155911 @default.
- W2066141010 hasRelatedWork W4239506746 @default.
- W2066141010 hasRelatedWork W2089279248 @default.
- W2066141010 isParatext "false" @default.
- W2066141010 isRetracted "false" @default.
- W2066141010 magId "2066141010" @default.
- W2066141010 workType "article" @default.