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• W2066152029 abstract "Saffron corms contain a proteoglycan that is highly cytotoxic on human tumor cells. The present work was undertaken to study the possible immunomodulatory and anti-invasive properties of this compound. Non-cytotoxic concentrations of this glycoconjugate promoted significant macrophage activation, detected by the release of nitric oxide. A rapid activation of protein kinase C and NF-kappaB was obtained after proteoglycan treatment, which could explain the induction of nitric oxide synthase. Proteoglycan concentrations ranging from 10-1000 ng/ml specifically promoted apoptosis of macrophages, probably triggered by their activation. This molecule did not inhibit in vitro migration or invasion of human tumor cells. Altogether these results support a plausible immuno-modulating activity for this saffron Crocus compound." @default.
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• W2066152029 date "1999-09-01" @default.
• W2066152029 modified "2023-10-18" @default.
• W2066152029 title "In vitro activation of macrophages by a novel proteoglycan isolated from corms of Crocus sativus L" @default.
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• W2066152029 doi "https://doi.org/10.1016/s0304-3835(99)00211-6" @default.
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