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- W2066157088 abstract "During the last 15 years, treatment of patients with metastatic colorectal cancer (mCRC) has undergone major improvements. First-line treatment combination regimen with 5-fluorouracil and irinotecan (FOLFIRI) was associated with a significant increase in overall survival [ [1] Douillard J.Y. Cunningham D. Roth A.D. et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet. 2000; 355: 1041-1047 Abstract Full Text Full Text PDF PubMed Scopus (3051) Google Scholar ]. The addition of biological agents to chemotherapy, such as the anti-vascular endothelial growth factor and anti-epidermal growth factor receptor monoclonal antibodies bevacizumab and cetuximab [ 2 Hurwitz H. Fehrenbacher L. Novotny W. et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. New England Journal of Medicine. 2004; 350: 2335-2342 Crossref PubMed Scopus (9322) Google Scholar , 3 Van Cutsem E. Kohne C.H. Lang I. et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. Journal of Clinical Oncology. 2011; 29: 2011-2019 Crossref PubMed Scopus (1553) Google Scholar ] increased survival compared to chemotherapy alone. The duration of first-line combination chemotherapy has been questioned because of toxicities during long treatments, with a negative impact on patient quality of life. Three phase III studies evaluating sequential chemotherapy (first-line fluoropyrimidine monotherapy followed by second-line dual chemotherapy in case of progressive disease) revealed no survival advantage compared to first-line combination [ 4 Ducreux M. Malka D. Mendiboure J. et al. Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000–05): an open-label, randomised, phase 3 trial. Lancet Oncology. 2011; 12: 1032-1044 Abstract Full Text Full Text PDF PubMed Scopus (121) Google Scholar , 5 Koopman M. Antonini N.F. Douma J. et al. Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial. Lancet. 2007; 370: 135-142 Abstract Full Text Full Text PDF PubMed Scopus (554) Google Scholar , 6 Seymour M.T. Maughan T.S. Ledermann J.A. et al. Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial. Lancet. 2007; 370: 143-152 Abstract Full Text Full Text PDF PubMed Scopus (490) Google Scholar ]. Therefore, a “step-up” strategy became an option in mCRC but has never been evaluated with regimens including biological agents." @default.
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- W2066157088 date "2015-04-01" @default.
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- W2066157088 title "FOLFIRI+bevacizumab induction chemotherapy followed by bevacizumab or observation in metastatic colorectal cancer, a phase III trial (PRODIGE 9 – FFCD 0802)" @default.
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- W2066157088 doi "https://doi.org/10.1016/j.dld.2015.01.146" @default.
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