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• W2066165628 abstract "Old drugs new tricks: Zopolrestat, an aldose reductase inhibitor developed by Pfizer for the treatment of diabetic complications, is a potent competition inhibitor of human glyoxalase I (GLOI) in vitro. Crystal structures of GLOI in complex with zopolrestat and indomethacin, a nonsteroidal anti-inflammatory drug and moderate inhibitor of GLOI, provide a structural basis for the development of novel GLOI inhibitors with excellent pharmacokinetics profiles." @default.
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• W2066165628 date "2013-07-15" @default.
• W2066165628 modified "2023-09-26" @default.
• W2066165628 title "Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis" @default.
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• W2066165628 doi "https://doi.org/10.1002/cmdc.201300243" @default.
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