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• W2066170147 abstract "We investigated here the mechanism leading to the enhancement of interleukin (IL)-2 mRNA that we described in a previous work when Jurkat cells were co-stimulated with PHA + PMA and 10−12 M of the Substance P (SP) neuropeptide. We show that the SP-augmented IL-2 mRNA signal is totally abrogated by an early addition of cyclosporin A, actinomycin D or cycloheximide. SP does not affect the IL-2 gene transcription, as evidenced by nuclear run on assays. In contrast, a posttranscriptional alteration of the IL-2 mRNA is shown, by demonstrating that the degradation rate of IL-2 mRNA following the addition of actinomycin D, at 4 h, was delayed in the (PHA + PMA)-activated cell cultures containing 10−12 M of SP. Thus, the SP-induced augmentation of secreted IL-2 in activated T cells we demonstrated previously must result from an SP increase of the IL-2 mRNA stability." @default.
• W2066170147 created "2016-06-24" @default.
• W2066170147 creator A5043217596 @default.
• W2066170147 date "1994-04-01" @default.
• W2066170147 modified "2023-10-18" @default.
• W2066170147 title "Substance P stabilizes interleukin-2 mRNA in activated Jurkat cells" @default.
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• W2066170147 doi "https://doi.org/10.1016/0165-5728(94)90132-5" @default.
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