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• W2066174966 abstract "A technique for determination of the prostaglandin E2 biosynthetic capacity ( PGBC ) of gastric mucosa is described. The effects of food deprivation and indomethacin pretreatment on PGBC were studied. Indomethacin (1 mg/kg i.p.) significantly reduced the PGBC of fundal and antral tissue. This effect was more marked in the fundal tissue. Food deprivation for up to 22 h had no effect on fundal PGBC . In the antrum, a 12-hour fast caused a significant reduction in PGBC while a 22-hour fast had no effect. These changes in PGBC may relate to the increase in susceptibility to gastric ulceration caused by fasting or indomethacin pretreatment. This technique may be applicable to clinical studies." @default.
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• W2066174966 date "1984-06-01" @default.
• W2066174966 modified "2023-10-03" @default.
• W2066174966 title "Prostaglandin biosynthesis by gastric mucosa. I. Studies in rat" @default.
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• W2066174966 doi "https://doi.org/10.1016/s0009-9120(84)80155-1" @default.
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