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- W2066176994 abstract "Acyltransferases are present in microsomes from alveolar type II cell adenomas (produced by urethan injections) that transfer palmitic acid in the presence of CoA, ATP, and Mg++ to sn-glycerol-3-P to form phosphatidic acid, to dihydroxyacetone-P to form acyldihydroxyacetone-P, and to 1-acyl-sn-glycero-3-phosphocholine to form 3-sn-phosphatidylcholine. The data clearly demonstrate that the microsomal preparations can catalyze significant incorporation of palmitic acid into the 2-position of the disaturated species of 3-sn-phosphatidylcholine independently of phosphatidic acid formation as evidenced by the fact that sn-glycerol-3-P and calcium ions (which inhibit choline phosphotransferase) did not influence the incorporation of palmitic acid into the main surfactant lipid. Thus, a deacylation-acylation reaction involving 2-lysophosphatidylcholine appears to be an important pathway for the synthesis of surfactant lipid in alveolar type II cells; the control of acyl specificity at the 2-position is determined by the relative concentrations of the coparticipating substrates, l-palmitoyl-sn-glycero-3-phosphocholine and palmitoyl-CoA." @default.
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- W2066176994 title "Acyltransferases and the biosynthesis of pulmonary surfactant lipid in adenoma alveolar type II cells" @default.
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- W2066176994 doi "https://doi.org/10.1016/0006-291x(75)90727-5" @default.
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