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- W2066184493 abstract "Homocytotropic antibodies capable of sensitizing calf skin were demonstrated in serum of cows as early as 7 to 9 days following antigenic stimulation with rabbit serum albumin. In addition, the antibody was present in colostrum of the immunized dam and was taken up by the intestine of the newborn calf as an intact molecule. Skin-sensitizing activity was also detected in calf urine after uptake of colostrum. Evidence is presented for an anamnestic response, suggesting the existence of an immunological memory for the formation of skin-sensitizing antibodies. The homocytotropic antibody was shown to be heat labile and sensitive to treatment with 2-mercaptoethanol. Time course studies revealed that homocytotropic antibodies persist in calf skin for at least 8 weeks. The immunoglobulin class associated with homocytotropic activity was enriched from appropriate antisera by salt precipitation, DEAE-cellulose chromatography and gel filtration on Sephadex G-200 columns. The final preparation was still capable of sensitizing calf skin for positive PCA reactions using a minimum dose of 0.009 μg N. The homocytotropic activity of the vinal fraction could not be removed by antibodies specific for the IgG class, but was completely blocked by antibodies against the fraction enriched in homocytotropic activity. The immunoglobulin class associated with skin-sensitizing activity possesses antigenic determinants which are lacking in μ-, α-, and γ-chains. The results indicate that the homocytotropic activity in the bovine species is associated with a unique immunoglobulin class analogous to human IgE." @default.
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- W2066184493 title "Detection of homocytotropic antibody associated with a unique immunoglobulin class in the bovine species" @default.
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- W2066184493 doi "https://doi.org/10.1002/eji.1830010407" @default.
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