FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066186143> ?p ?o ?g. }

• W2066186143 endingPage "3344" @default.
• W2066186143 startingPage "3332" @default.
• W2066186143 abstract "In this paper, we explore the use of Neusilin, an inorganic magnesium aluminometasilicate, to stabilize the amorphous form of an acidic drug Sulindac. Both cryomilling and ball milling of the drug with Neusilin were found to produce the amorphous phase. However, the ball‐milled (BM) material exhibited superior physical stability when compared with the cryomilled material at 40°C/75% relative humidity. 13C solid‐state nuclear magnetic resonance investigation of the BM material revealed an acid–base reaction between Sulindac and Neusilin. Optimal milling conditions and the kinetics of salt formation were also established. As benchtop milling is a laboratory‐scale process, a scalable process was developed to make Sulindac–Neusilin amorphous drug complex using hot‐melt extrusion (HME). The dissolution properties of the resulting HME material was found to have been improved over the material made by benchtop milling while maintaining similar physical stability. The HME material was used to make tablets using a direct compression method. The HME tablets were found to have better dissolution properties than tablets made from crystalline Sulindac. For the broad class of acidic drugs containing the carboxyl moiety, inorganic silicates such as Neusilin would offer a better choice than organic polymers to stabilize the amorphous phase. © 2011 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3332–3344, 2011" @default.
• W2066186143 created "2016-06-24" @default.
• W2066186143 creator A5007624826 @default.
• W2066186143 creator A5022192888 @default.
• W2066186143 creator A5042187759 @default.
• W2066186143 creator A5058330415 @default.
• W2066186143 creator A5074993745 @default.
• W2066186143 creator A5087315481 @default.
• W2066186143 creator A5071066049 @default.
• W2066186143 date "2011-08-01" @default.
• W2066186143 modified "2023-10-10" @default.
• W2066186143 title "Manufacture and Performance Evaluation of a Stable Amorphous Complex of an Acidic Drug Molecule and Neusilin" @default.
• W2066186143 cites W1963483812 @default.
• W2066186143 cites W1963852040 @default.
• W2066186143 cites W1967935934 @default.
• W2066186143 cites W1973040104 @default.
• W2066186143 cites W1976376411 @default.
• W2066186143 cites W1989461604 @default.
• W2066186143 cites W1994893251 @default.
• W2066186143 cites W1997341902 @default.
• W2066186143 cites W1998154319 @default.
• W2066186143 cites W2033263770 @default.
• W2066186143 cites W2033721542 @default.
• W2066186143 cites W2039163843 @default.
• W2066186143 cites W2039290656 @default.
• W2066186143 cites W2042245076 @default.
• W2066186143 cites W2048360669 @default.
• W2066186143 cites W2048677962 @default.
• W2066186143 cites W2050605777 @default.
• W2066186143 cites W2054456522 @default.
• W2066186143 cites W2059365736 @default.
• W2066186143 cites W2060647644 @default.
• W2066186143 cites W2064605784 @default.
• W2066186143 cites W2067507455 @default.
• W2066186143 cites W2073776376 @default.
• W2066186143 cites W2076269997 @default.
• W2066186143 cites W2082209609 @default.
• W2066186143 cites W2094281435 @default.
• W2066186143 cites W2097577562 @default.
• W2066186143 cites W2108831505 @default.
• W2066186143 cites W2320457949 @default.
• W2066186143 cites W2322987975 @default.
• W2066186143 doi "https://doi.org/10.1002/jps.22583" @default.
• W2066186143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21520086" @default.
• W2066186143 hasPublicationYear "2011" @default.
• W2066186143 type Work @default.
• W2066186143 sameAs 2066186143 @default.
• W2066186143 citedByCount "39" @default.
• W2066186143 countsByYear W20661861432012 @default.
• W2066186143 countsByYear W20661861432013 @default.
• W2066186143 countsByYear W20661861432014 @default.
• W2066186143 countsByYear W20661861432015 @default.
• W2066186143 countsByYear W20661861432016 @default.
• W2066186143 countsByYear W20661861432017 @default.
• W2066186143 countsByYear W20661861432018 @default.
• W2066186143 countsByYear W20661861432019 @default.
• W2066186143 countsByYear W20661861432020 @default.
• W2066186143 countsByYear W20661861432021 @default.
• W2066186143 countsByYear W20661861432022 @default.
• W2066186143 countsByYear W20661861432023 @default.
• W2066186143 crossrefType "journal-article" @default.
• W2066186143 hasAuthorship W2066186143A5007624826 @default.
• W2066186143 hasAuthorship W2066186143A5022192888 @default.
• W2066186143 hasAuthorship W2066186143A5042187759 @default.
• W2066186143 hasAuthorship W2066186143A5058330415 @default.
• W2066186143 hasAuthorship W2066186143A5071066049 @default.
• W2066186143 hasAuthorship W2066186143A5074993745 @default.
• W2066186143 hasAuthorship W2066186143A5087315481 @default.
• W2066186143 hasConcept C127413603 @default.
• W2066186143 hasConcept C132186339 @default.
• W2066186143 hasConcept C155574463 @default.
• W2066186143 hasConcept C178790620 @default.
• W2066186143 hasConcept C185592680 @default.
• W2066186143 hasConcept C191897082 @default.
• W2066186143 hasConcept C192562407 @default.
• W2066186143 hasConcept C42360764 @default.
• W2066186143 hasConcept C56052488 @default.
• W2066186143 hasConcept C88380143 @default.
• W2066186143 hasConceptScore W2066186143C127413603 @default.
• W2066186143 hasConceptScore W2066186143C132186339 @default.
• W2066186143 hasConceptScore W2066186143C155574463 @default.
• W2066186143 hasConceptScore W2066186143C178790620 @default.
• W2066186143 hasConceptScore W2066186143C185592680 @default.
• W2066186143 hasConceptScore W2066186143C191897082 @default.
• W2066186143 hasConceptScore W2066186143C192562407 @default.
• W2066186143 hasConceptScore W2066186143C42360764 @default.
• W2066186143 hasConceptScore W2066186143C56052488 @default.
• W2066186143 hasConceptScore W2066186143C88380143 @default.
• W2066186143 hasIssue "8" @default.
• W2066186143 hasLocation W20661861431 @default.
• W2066186143 hasLocation W20661861432 @default.
• W2066186143 hasOpenAccess W2066186143 @default.
• W2066186143 hasPrimaryLocation W20661861431 @default.
• W2066186143 hasRelatedWork W1971760344 @default.
• W2066186143 hasRelatedWork W1986576703 @default.
• W2066186143 hasRelatedWork W2005165574 @default.
• W2066186143 hasRelatedWork W2046158925 @default.
• W2066186143 hasRelatedWork W2093113994 @default.

• next