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• W2066191837 startingPage "7861" @default.
• W2066191837 abstract "Motivated by our recent finding that 4‘-ethynylstavudine (4) is a promising anti-human immunodeficiency virus type 1 (HIV-1) agent, we synthesized its 4‘-thio analogue, as well as other 4‘-thiostavudines having a carbon substituent at the 4‘-position, as racemates in this study. Methyl 3-oxo-tetrahydrothiophen-2-carboxylate (5) was used as a starting material to construct the requisite 4-thiofuranoid glycal (13). Introduction of a thymine base was carried out by an electrophilic addition reaction to 13 using N-iodosuccinimide (NIS) and bis(trimethylsilyl)thymine. The desired β-anomer (16β) obtained as a major product in this reaction underwent ready elimination with activated Zn to give the 4‘-carbomethoxy derivative (18). By using 18 as a common intermediate, 4‘-carbon-substituted (CH2OH, CO2Me, CONH2, CHCH2, CN, and C⋮CH) 4‘-thiostavudines were prepared. Among these six compounds, 4‘-cyano (28) and 4‘-ethynyl (29) analogues were found to show inhibitory activity against HIV-1 with ED50 values of 7.6 and 0.74 μM, respectively. The activity of 29 was comparable to that of stavudine, but 29 was not as active as 4. Optical resolution of 29 was briefly examined." @default.
• W2066191837 created "2016-06-24" @default.
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• W2066191837 date "2006-12-01" @default.
• W2066191837 modified "2023-09-22" @default.
• W2066191837 title "Synthesis and Anti-Human Immunodeficiency Virus Activity of 4‘-Branched (±)-4‘-Thiostavudines" @default.
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• W2066191837 doi "https://doi.org/10.1021/jm060980j" @default.
• W2066191837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17181169" @default.
• W2066191837 hasPublicationYear "2006" @default.
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