Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066192511> ?p ?o ?g. }
- W2066192511 endingPage "105" @default.
- W2066192511 startingPage "97" @default.
- W2066192511 abstract "Astrocytes respond to multiple forms of central nervous system (CNS) injury by entering a reactive state characterized by morphological changes and a specific pattern of altered protein expression. Termed astrogliosis, this response has been shown to strongly influence the injury response and functional recovery of CNS tissues. This pattern of CNS inflammation and injury associated with astrogliosis has recently been found to occur in the energy homeostasis centers of the hypothalamus during diet-induced obesity (DIO) in rodent models, but the characterization of the astrocyte response remains incomplete. Here, we report that astrocytes in the mediobasal hypothalamus respond robustly and rapidly to purified high-fat diet (HFD) feeding by cleaving caspase-3, a protease whose cleavage is often associated with apoptosis. Although obesity develops in HFD-fed rats by day 14, caspase-3 cleavage occurs by day 3, prior to the development of obesity, suggesting the possibility that it could play a causal role in the hypothalamic neuropathology and fat gain observed in DIO. Caspase-3 cleavage is not associated with an increase in the rate of apoptosis, as determined by TUNEL staining, suggesting it plays a non-apoptotic role analogous to the response to excitotoxic neuron injury. Our results indicate that astrocytes in the mediobasal hypothalamus respond rapidly and robustly to HFD feeding, activating caspase-3 in the absence of apoptosis, a process that has the potential to influence the course of DIO." @default.
- W2066192511 created "2016-06-24" @default.
- W2066192511 creator A5013784745 @default.
- W2066192511 creator A5021482790 @default.
- W2066192511 creator A5023048372 @default.
- W2066192511 creator A5035450241 @default.
- W2066192511 creator A5053926256 @default.
- W2066192511 creator A5088091814 @default.
- W2066192511 date "2013-05-01" @default.
- W2066192511 modified "2023-09-25" @default.
- W2066192511 title "High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes" @default.
- W2066192511 cites W1963857988 @default.
- W2066192511 cites W1964562779 @default.
- W2066192511 cites W1967912613 @default.
- W2066192511 cites W1984328054 @default.
- W2066192511 cites W1984737766 @default.
- W2066192511 cites W1999495459 @default.
- W2066192511 cites W2000844712 @default.
- W2066192511 cites W2008219426 @default.
- W2066192511 cites W2010788419 @default.
- W2066192511 cites W2012730798 @default.
- W2066192511 cites W2017946350 @default.
- W2066192511 cites W2019610319 @default.
- W2066192511 cites W2039188961 @default.
- W2066192511 cites W2042994791 @default.
- W2066192511 cites W2066292724 @default.
- W2066192511 cites W2068798911 @default.
- W2066192511 cites W2075792687 @default.
- W2066192511 cites W2077033935 @default.
- W2066192511 cites W2077335475 @default.
- W2066192511 cites W2103037576 @default.
- W2066192511 cites W2104141601 @default.
- W2066192511 cites W2109450020 @default.
- W2066192511 cites W2127338217 @default.
- W2066192511 cites W2135376726 @default.
- W2066192511 cites W2139230654 @default.
- W2066192511 cites W2142272708 @default.
- W2066192511 cites W2144419601 @default.
- W2066192511 cites W2144534316 @default.
- W2066192511 cites W2154696002 @default.
- W2066192511 cites W2154696007 @default.
- W2066192511 cites W2156796753 @default.
- W2066192511 cites W2158496649 @default.
- W2066192511 cites W2160935383 @default.
- W2066192511 cites W2166851454 @default.
- W2066192511 cites W4234971544 @default.
- W2066192511 doi "https://doi.org/10.1016/j.brainres.2013.03.033" @default.
- W2066192511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3684737" @default.
- W2066192511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23548599" @default.
- W2066192511 hasPublicationYear "2013" @default.
- W2066192511 type Work @default.
- W2066192511 sameAs 2066192511 @default.
- W2066192511 citedByCount "36" @default.
- W2066192511 countsByYear W20661925112013 @default.
- W2066192511 countsByYear W20661925112014 @default.
- W2066192511 countsByYear W20661925112015 @default.
- W2066192511 countsByYear W20661925112016 @default.
- W2066192511 countsByYear W20661925112017 @default.
- W2066192511 countsByYear W20661925112018 @default.
- W2066192511 countsByYear W20661925112019 @default.
- W2066192511 countsByYear W20661925112020 @default.
- W2066192511 countsByYear W20661925112021 @default.
- W2066192511 countsByYear W20661925112022 @default.
- W2066192511 countsByYear W20661925112023 @default.
- W2066192511 crossrefType "journal-article" @default.
- W2066192511 hasAuthorship W2066192511A5013784745 @default.
- W2066192511 hasAuthorship W2066192511A5021482790 @default.
- W2066192511 hasAuthorship W2066192511A5023048372 @default.
- W2066192511 hasAuthorship W2066192511A5035450241 @default.
- W2066192511 hasAuthorship W2066192511A5053926256 @default.
- W2066192511 hasAuthorship W2066192511A5088091814 @default.
- W2066192511 hasBestOaLocation W20661925112 @default.
- W2066192511 hasConcept C12519072 @default.
- W2066192511 hasConcept C126322002 @default.
- W2066192511 hasConcept C134018914 @default.
- W2066192511 hasConcept C169760540 @default.
- W2066192511 hasConcept C190283241 @default.
- W2066192511 hasConcept C196795494 @default.
- W2066192511 hasConcept C203014093 @default.
- W2066192511 hasConcept C204232928 @default.
- W2066192511 hasConcept C2491326 @default.
- W2066192511 hasConcept C2777003273 @default.
- W2066192511 hasConcept C2777542381 @default.
- W2066192511 hasConcept C2777682930 @default.
- W2066192511 hasConcept C2779965356 @default.
- W2066192511 hasConcept C2780495277 @default.
- W2066192511 hasConcept C2780884517 @default.
- W2066192511 hasConcept C31573885 @default.
- W2066192511 hasConcept C511355011 @default.
- W2066192511 hasConcept C529278444 @default.
- W2066192511 hasConcept C55493867 @default.
- W2066192511 hasConcept C71924100 @default.
- W2066192511 hasConcept C86803240 @default.
- W2066192511 hasConcept C95444343 @default.
- W2066192511 hasConcept C98424977 @default.
- W2066192511 hasConceptScore W2066192511C12519072 @default.
- W2066192511 hasConceptScore W2066192511C126322002 @default.
- W2066192511 hasConceptScore W2066192511C134018914 @default.