FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066197328> ?p ?o ?g. }

• W2066197328 endingPage "257" @default.
• W2066197328 startingPage "251" @default.
• W2066197328 abstract "NKG2D is one of the best characterized activating receptors on Natural Killer (NK) and CD8+ T cells. This receptor recognizes several different ligands (MICA/MICB and ULBPs) induced by cellular stress and infection. In addition to the role described in cancer surveillance, recent data highlight the importance of NKG2D and its ligands in organ transplantation. Allografts show evidence of MICA and MICB expression in both acute and chronic rejection. The presence of anti-MICA antibodies has been correlated with incidence of graft rejection. Furthermore, NKG2D-ligand engagement activates NK cells, which provides T-cell costimulation, and enhances antigen specific CTL-mediated cytotoxicity. Activated NK cells may function as a bridge between innate and adaptive immunity associated with transplantation. Activated NK cells in response to IL-15 can also trigger organ rejection through NKG2D and affect the maturation of both donor and recipient antigen presenting cells (APCs) and ultimately the T-cell allogeneic response. Regulatory T cells, which modulate T-cell responses in organ transplantation and infections, were reduced in numbers by NK cells exposed to intracellular pathogens, possibly via interaction with one NK2GD receptor. Blockage of NKG2D-NKG2D-L interactions provides a novel pathway for development of inhibitors. These studies have important clinical and therapeutic implications in solid organ transplantation." @default.
• W2066197328 created "2016-06-24" @default.
• W2066197328 creator A5001278301 @default.
• W2066197328 creator A5032408537 @default.
• W2066197328 creator A5039801227 @default.
• W2066197328 creator A5086263807 @default.
• W2066197328 creator A5091591327 @default.
• W2066197328 date "2009-02-01" @default.
• W2066197328 modified "2023-10-01" @default.
• W2066197328 title "Potential Role of NKG2D and Its Ligands in Organ Transplantation: New Target for Immunointervention" @default.
• W2066197328 cites W1502124510 @default.
• W2066197328 cites W1507607883 @default.
• W2066197328 cites W1593435314 @default.
• W2066197328 cites W1642294218 @default.
• W2066197328 cites W1665466173 @default.
• W2066197328 cites W1939978268 @default.
• W2066197328 cites W1964209790 @default.
• W2066197328 cites W1970527277 @default.
• W2066197328 cites W1973851782 @default.
• W2066197328 cites W1978496119 @default.
• W2066197328 cites W1985444402 @default.
• W2066197328 cites W1991966640 @default.
• W2066197328 cites W1993147375 @default.
• W2066197328 cites W1994085514 @default.
• W2066197328 cites W2002197941 @default.
• W2066197328 cites W2006202815 @default.
• W2066197328 cites W2012173650 @default.
• W2066197328 cites W2019963945 @default.
• W2066197328 cites W2023370541 @default.
• W2066197328 cites W2025881173 @default.
• W2066197328 cites W2032905248 @default.
• W2066197328 cites W2048250100 @default.
• W2066197328 cites W2058730772 @default.
• W2066197328 cites W2059976587 @default.
• W2066197328 cites W2061079054 @default.
• W2066197328 cites W2062407373 @default.
• W2066197328 cites W2062956351 @default.
• W2066197328 cites W2069474890 @default.
• W2066197328 cites W2076089115 @default.
• W2066197328 cites W2092409392 @default.
• W2066197328 cites W2101336470 @default.
• W2066197328 cites W2102090153 @default.
• W2066197328 cites W2119333066 @default.
• W2066197328 cites W2130625143 @default.
• W2066197328 cites W2130820062 @default.
• W2066197328 cites W2132143019 @default.
• W2066197328 cites W2145648067 @default.
• W2066197328 cites W2155879219 @default.
• W2066197328 doi "https://doi.org/10.1111/j.1600-6143.2008.02526.x" @default.
• W2066197328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19178412" @default.
• W2066197328 hasPublicationYear "2009" @default.
• W2066197328 type Work @default.
• W2066197328 sameAs 2066197328 @default.
• W2066197328 citedByCount "74" @default.
• W2066197328 countsByYear W20661973282012 @default.
• W2066197328 countsByYear W20661973282013 @default.
• W2066197328 countsByYear W20661973282014 @default.
• W2066197328 countsByYear W20661973282015 @default.
• W2066197328 countsByYear W20661973282016 @default.
• W2066197328 countsByYear W20661973282017 @default.
• W2066197328 countsByYear W20661973282018 @default.
• W2066197328 countsByYear W20661973282019 @default.
• W2066197328 countsByYear W20661973282020 @default.
• W2066197328 countsByYear W20661973282021 @default.
• W2066197328 countsByYear W20661973282022 @default.
• W2066197328 countsByYear W20661973282023 @default.
• W2066197328 crossrefType "journal-article" @default.
• W2066197328 hasAuthorship W2066197328A5001278301 @default.
• W2066197328 hasAuthorship W2066197328A5032408537 @default.
• W2066197328 hasAuthorship W2066197328A5039801227 @default.
• W2066197328 hasAuthorship W2066197328A5086263807 @default.
• W2066197328 hasAuthorship W2066197328A5091591327 @default.
• W2066197328 hasBestOaLocation W20661973281 @default.
• W2066197328 hasConcept C126322002 @default.
• W2066197328 hasConcept C154317977 @default.
• W2066197328 hasConcept C167672396 @default.
• W2066197328 hasConcept C202751555 @default.
• W2066197328 hasConcept C203014093 @default.
• W2066197328 hasConcept C2778102761 @default.
• W2066197328 hasConcept C2778867473 @default.
• W2066197328 hasConcept C2911091166 @default.
• W2066197328 hasConcept C502942594 @default.
• W2066197328 hasConcept C55493867 @default.
• W2066197328 hasConcept C71924100 @default.
• W2066197328 hasConcept C86803240 @default.
• W2066197328 hasConcept C8891405 @default.
• W2066197328 hasConcept C95444343 @default.
• W2066197328 hasConceptScore W2066197328C126322002 @default.
• W2066197328 hasConceptScore W2066197328C154317977 @default.
• W2066197328 hasConceptScore W2066197328C167672396 @default.
• W2066197328 hasConceptScore W2066197328C202751555 @default.
• W2066197328 hasConceptScore W2066197328C203014093 @default.
• W2066197328 hasConceptScore W2066197328C2778102761 @default.
• W2066197328 hasConceptScore W2066197328C2778867473 @default.
• W2066197328 hasConceptScore W2066197328C2911091166 @default.
• W2066197328 hasConceptScore W2066197328C502942594 @default.
• W2066197328 hasConceptScore W2066197328C55493867 @default.
• W2066197328 hasConceptScore W2066197328C71924100 @default.

• next