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- W2066200053 abstract "Two compounds, NF-167 (5-nitro-2-furaldehyde-5-[3-diethylaminopropyl] semioxamazone hydrochloride) and metronidazole (2-methyl-5-nitroimidazole-1-ethanol), were selected for in vitro testing of their abilities to sensitize hypoxic KHT tumor cells to ionizing radiation. Metronidazole had been shown previously to sensitize hypoxic KHT cells in mice while NF-167 had shown no in vivo sensitization. The acute and chronic toxicities of the drugs were determined and then sensitization was measured after a single dose of radiation as a function of drug concentration. Survival curves were determined at a cell concentration of $5times 10^{5} text{cells}/{rm ml}$ using 27 μM NF-167 and 5.8 and 29 mM metronidazole. The enhancement ratio of NF-167 was found to be 1.5, and that of metronidazole was 1.4. The effect of cell density on the sensitizing abilities of these compounds was investigated and it was found that at densities near $10^{8} text{cells}/{rm ml}$ NF-167 lo..." @default.
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- W2066200053 date "1974-12-01" @default.
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- W2066200053 title "A Comparison of the Effectiveness of NF-167 and Metronidazole as Hypoxic Cell Sensitizers of KHT Tumor Cells in Vitro" @default.
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- W2066200053 doi "https://doi.org/10.2307/3574028" @default.
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