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- W2066207306 abstract "Abstract Aquaporin 0 (AQP0) and AQP1 are expressed in the lens, each in a different cell type, and their functional roles are not thoroughly understood. Our previous study showed that these two AQPs function as water transporters. In order to further understand the functional significance of these two different aquaporins in the lens, we investigated their initiation and continued expression. AQP0 transcript and protein were first detected at embryonic stage (E) 11.25 in the differentiating primary fiber cells of the developing lens; its synthesis continued through the adult stage in the secondary fiber cells. Low levels of AQP1 expression were first seen in lens anterior epithelial cells at E17.5; following postnatal day (P) 6.5, the expression gradually progressed towards the equatorial epithelial cells. In the postnatal lens, the increase in membrane water permeability of epithelial cells and lens transparency coincides with the increase in AQP1 expression. AQP1 expression reaches its peak at P30 and continues through the adult stage both in the anterior and equatorial epithelial cells. The enhancement in AQP1 expression concomitant with the increase in the size of the lens suggests the progression in the establishment of the lens microcirculatory system. In vitro and in vivo studies show that both aquaporins share at least one important function, which is water transport in the lens microcirculatory system. However, the temporal expression of these two AQPs suggests an apparently unique role/s in lens development and transparency. To our knowledge, this is the first report on the expression patterns of AQP0 and AQP1 during lens development and differentiation and their relation to lens transparency. Developmental Dynamics 236:1319–1328, 2007. © 2007 Wiley‐Liss, Inc." @default.
- W2066207306 created "2016-06-24" @default.
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- W2066207306 date "2007-03-21" @default.
- W2066207306 modified "2023-10-16" @default.
- W2066207306 title "Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses" @default.
- W2066207306 cites W1499625143 @default.
- W2066207306 cites W1533772500 @default.
- W2066207306 cites W1565788411 @default.
- W2066207306 cites W1917414630 @default.
- W2066207306 cites W1963539914 @default.
- W2066207306 cites W1968987375 @default.
- W2066207306 cites W1971226411 @default.
- W2066207306 cites W1974595401 @default.
- W2066207306 cites W1975517087 @default.
- W2066207306 cites W1978679800 @default.
- W2066207306 cites W1981085873 @default.
- W2066207306 cites W1982731004 @default.
- W2066207306 cites W1983895641 @default.
- W2066207306 cites W1984284559 @default.
- W2066207306 cites W1994050512 @default.
- W2066207306 cites W1995419987 @default.
- W2066207306 cites W1995503611 @default.
- W2066207306 cites W1995540745 @default.
- W2066207306 cites W1998925732 @default.
- W2066207306 cites W1998953734 @default.
- W2066207306 cites W2003632722 @default.
- W2066207306 cites W2005664680 @default.
- W2066207306 cites W2008726342 @default.
- W2066207306 cites W2009955844 @default.
- W2066207306 cites W2013346680 @default.
- W2066207306 cites W2015698711 @default.
- W2066207306 cites W2023392253 @default.
- W2066207306 cites W2025744801 @default.
- W2066207306 cites W2028918602 @default.
- W2066207306 cites W2029360750 @default.
- W2066207306 cites W2030900937 @default.
- W2066207306 cites W2031290338 @default.
- W2066207306 cites W2036314401 @default.
- W2066207306 cites W2037141661 @default.
- W2066207306 cites W2040590123 @default.
- W2066207306 cites W2042000969 @default.
- W2066207306 cites W2042282096 @default.
- W2066207306 cites W2045388418 @default.
- W2066207306 cites W2050820564 @default.
- W2066207306 cites W2052922251 @default.
- W2066207306 cites W2061789286 @default.
- W2066207306 cites W2063034492 @default.
- W2066207306 cites W2069036744 @default.
- W2066207306 cites W2071335303 @default.
- W2066207306 cites W2079126167 @default.
- W2066207306 cites W2080007006 @default.
- W2066207306 cites W2084179773 @default.
- W2066207306 cites W2088999402 @default.
- W2066207306 cites W2090182712 @default.
- W2066207306 cites W2090275726 @default.
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- W2066207306 cites W2098730572 @default.
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- W2066207306 cites W2106912222 @default.
- W2066207306 cites W2115148652 @default.
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- W2066207306 cites W2139491256 @default.
- W2066207306 cites W2144562003 @default.
- W2066207306 cites W2148071530 @default.
- W2066207306 cites W2156852165 @default.
- W2066207306 cites W2160851503 @default.
- W2066207306 cites W2166296473 @default.
- W2066207306 cites W2168734089 @default.
- W2066207306 cites W2170562984 @default.
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- W2066207306 doi "https://doi.org/10.1002/dvdy.21125" @default.
- W2066207306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2534140" @default.
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- W2066207306 hasPublicationYear "2007" @default.
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