FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066225797> ?p ?o ?g. }

• W2066225797 endingPage "653" @default.
• W2066225797 startingPage "646" @default.
• W2066225797 abstract "I.V. pentamidine therapy in HIV-infected patients has been associated in case reports and one uncontrolled prospective series with frequent prolongation of the rate-corrected QT interval (QTc) and a high risk for potentially lethal ventricular arrhythmias, especially torsade de pointes. The aim of this study was to prospectively examine in a controlled manner the effect of I.V. pentamidine therapy on the QT interval and the incidence of ventricular arrhythmias.Open, nonrandomized, prospective evaluation of ventricular arrhythmia incidence in HIV-infected patients receiving pentamidine or trimethoprim-sulfamethoxazole (TMP-SMX) utilizing Holter monitoring prior to and during therapy with these agents.Staten Island University Hospital, Staten Island, NY.Twenty-seven HIV-infected patients, of whom 16 received I.V. pentamidine and 11 received I.V. TMP-SMX.Study patients underwent Holter monitoring prior to therapy and during the first 3 days and last 2 days of therapy with pentamidine or TMP-SMX, 12-lead ECG prior to and every 24 to 48 h, serum electrolytes prior to and on days 3, 6, 9, and 12 of therapy, and baseline transthoracic two-dimensional and Doppler echocardiography. In the pentamidine group, the results for each monitoring period were as follows (means are presented +/- SEM): pretherapy, 1.66+/-1.03 (median=0) premature ventricular complexes (PVCs) per hour, zero nonsustained ventricular tachycardia (NSVT), zero sustained ventricular tachycardia (VT); early therapy, 1.55+/-0.91 (median=0.04) PVCs per hour, two NSVT (both < or = 5 complexes), zero sustained VT; late therapy, 1.69+/-1.17 (median=0.08) PVCs per hour, zero NSVT, zero sustained VT (p value not significant for early or late therapy as compared to pretherapy for PVCs per hour, NSVT, or sustained VT). In the TMP-SMX group, the Holter monitoring results were as follows: pretherapy, 1.36+/-1.27 (median=0) PVCs per hour, zero NSVT, zero sustained VT; early therapy, 0.71+/-0.53 (median=0.03) PVCs per hour, two NSVT, zero sustained VT; late therapy, 0.56+/-0.51 (median=0) PVCs per hour, zero NSVT, zero sustained VT (p value not significant for pretherapy, early therapy, or late therapy with TMP-SMX as compared to pentamidine for PVCs per hour, NSVT, or VT). The QTc also did not significantly differ during therapy with pentamidine as compared to TMP-SMX. The mean QTc in the pentamidine group decreased during therapy as compared to pretherapy with the difference approaching significance for days 2, 4, and 6 with pentamidine (p<0.06).QTc prolongation during therapy with pentamidine in HIV-infected patients is not as frequent an occurrence as has been reported previously. In the absence of QTc prolongation, pentamidine therapy was not associated with a significant increase in PVCs, NSVT, or sustained VT as compared to pretherapy recordings or as compared to therapy with TMP-SMX." @default.
• W2066225797 created "2016-06-24" @default.
• W2066225797 creator A5002405762 @default.
• W2066225797 creator A5041241921 @default.
• W2066225797 creator A5042110481 @default.
• W2066225797 creator A5054037354 @default.
• W2066225797 creator A5068193554 @default.
• W2066225797 creator A5069891214 @default.
• W2066225797 creator A5078933052 @default.
• W2066225797 date "1997-09-01" @default.
• W2066225797 modified "2023-09-23" @default.
• W2066225797 title "A Prospective Study of the Effect of IV Pentamidine Therapy on Ventricular Arrhythmias and QTc Prolongation in HIV-infected Patients" @default.
• W2066225797 cites W1981058517 @default.
• W2066225797 cites W1985650080 @default.
• W2066225797 cites W1994965173 @default.
• W2066225797 cites W2002737978 @default.
• W2066225797 cites W2013208067 @default.
• W2066225797 cites W2029350931 @default.
• W2066225797 cites W2035364159 @default.
• W2066225797 cites W2035829434 @default.
• W2066225797 cites W2047018997 @default.
• W2066225797 cites W2072525437 @default.
• W2066225797 cites W2123517830 @default.
• W2066225797 cites W2161275399 @default.
• W2066225797 cites W2169942824 @default.
• W2066225797 cites W3024876814 @default.
• W2066225797 doi "https://doi.org/10.1378/chest.112.3.646" @default.
• W2066225797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9315796" @default.
• W2066225797 hasPublicationYear "1997" @default.
• W2066225797 type Work @default.
• W2066225797 sameAs 2066225797 @default.
• W2066225797 citedByCount "41" @default.
• W2066225797 countsByYear W20662257972012 @default.
• W2066225797 countsByYear W20662257972013 @default.
• W2066225797 countsByYear W20662257972014 @default.
• W2066225797 countsByYear W20662257972015 @default.
• W2066225797 countsByYear W20662257972017 @default.
• W2066225797 countsByYear W20662257972018 @default.
• W2066225797 countsByYear W20662257972019 @default.
• W2066225797 countsByYear W20662257972022 @default.
• W2066225797 countsByYear W20662257972023 @default.
• W2066225797 crossrefType "journal-article" @default.
• W2066225797 hasAuthorship W2066225797A5002405762 @default.
• W2066225797 hasAuthorship W2066225797A5041241921 @default.
• W2066225797 hasAuthorship W2066225797A5042110481 @default.
• W2066225797 hasAuthorship W2066225797A5054037354 @default.
• W2066225797 hasAuthorship W2066225797A5068193554 @default.
• W2066225797 hasAuthorship W2066225797A5069891214 @default.
• W2066225797 hasAuthorship W2066225797A5078933052 @default.
• W2066225797 hasConcept C118441451 @default.
• W2066225797 hasConcept C120665830 @default.
• W2066225797 hasConcept C121332964 @default.
• W2066225797 hasConcept C126322002 @default.
• W2066225797 hasConcept C164705383 @default.
• W2066225797 hasConcept C188816634 @default.
• W2066225797 hasConcept C2776331378 @default.
• W2066225797 hasConcept C2777530519 @default.
• W2066225797 hasConcept C2777914695 @default.
• W2066225797 hasConcept C42219234 @default.
• W2066225797 hasConcept C61511704 @default.
• W2066225797 hasConcept C71924100 @default.
• W2066225797 hasConceptScore W2066225797C118441451 @default.
• W2066225797 hasConceptScore W2066225797C120665830 @default.
• W2066225797 hasConceptScore W2066225797C121332964 @default.
• W2066225797 hasConceptScore W2066225797C126322002 @default.
• W2066225797 hasConceptScore W2066225797C164705383 @default.
• W2066225797 hasConceptScore W2066225797C188816634 @default.
• W2066225797 hasConceptScore W2066225797C2776331378 @default.
• W2066225797 hasConceptScore W2066225797C2777530519 @default.
• W2066225797 hasConceptScore W2066225797C2777914695 @default.
• W2066225797 hasConceptScore W2066225797C42219234 @default.
• W2066225797 hasConceptScore W2066225797C61511704 @default.
• W2066225797 hasConceptScore W2066225797C71924100 @default.
• W2066225797 hasIssue "3" @default.
• W2066225797 hasLocation W20662257971 @default.
• W2066225797 hasLocation W20662257972 @default.
• W2066225797 hasOpenAccess W2066225797 @default.
• W2066225797 hasPrimaryLocation W20662257971 @default.
• W2066225797 hasRelatedWork W1981058517 @default.
• W2066225797 hasRelatedWork W2003017705 @default.
• W2066225797 hasRelatedWork W2033563995 @default.
• W2066225797 hasRelatedWork W2050329708 @default.
• W2066225797 hasRelatedWork W2066225797 @default.
• W2066225797 hasRelatedWork W2066590515 @default.
• W2066225797 hasRelatedWork W2072525437 @default.
• W2066225797 hasRelatedWork W2075503497 @default.
• W2066225797 hasRelatedWork W2319071034 @default.
• W2066225797 hasRelatedWork W2319980369 @default.
• W2066225797 hasVolume "112" @default.
• W2066225797 isParatext "false" @default.
• W2066225797 isRetracted "false" @default.
• W2066225797 magId "2066225797" @default.
• W2066225797 workType "article" @default.