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• W2066232579 abstract "Interaction between CD27 and its ligand CD70 provides a second signal for T-cell proliferation and tumour necrosis factor-alpha (TNF-alpha) production. Whereas CD27 is broadly expressed during T-cell development, expression of CD70 in vivo is restricted. To determine when CD27 CD70 interactions can occur in immune reactions, we here analysed the regulation of CD70 expression on activated T cells. Mitogenic stimulation of purified T cells with either immobilized CD3 monoclonal antibody (mAb) or a combination of CD2 mAb induces only low levels of CD70 membrane expression. Markedly expression of the CD27-ligand is strongly enhanced by antigen-presenting cells (APC) and APC-associated signals such as interleukin-1 alpha (IL-1 alpha). IL-12, TNF-alpha and CD28-ligation. In contrast, T-cell derived cytokines, such as IL-4, counteract CD70 up-regulation on activated T cells. Analysis of the small subset of circulating CD70+ T cells revealed that these cells have a primed phenotype as they express CD45RO and HLA-DR antigens and are in high frequency able to secrete interferon-gamma (IFN-gamma). We conclude that T-T interactions involving CD27 and CD70 are likely to occur relatively early in immune reactions, after productive T-cell priming by APC and that expression of CD70 on circulating T cells is a reflection of recent priming by antigen." @default.
• W2066232579 created "2016-06-24" @default.
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• W2066232579 date "1997-01-01" @default.
• W2066232579 modified "2023-10-16" @default.
• W2066232579 title "Antigen‐presenting cell‐derived signals determine expression levels of CD70 on‘qc primed T cells" @default.
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• W2066232579 doi "https://doi.org/10.1046/j.1365-2567.1997.00134.x" @default.
• W2066232579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1456715" @default.
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• W2066232579 hasPublicationYear "1997" @default.
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