Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066273583> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2066273583 abstract "The neurofibromatosis type 2 (NF2) tumor suppressor gene encodes a cytoskeletal/membranous protein, Merlin. Inactivation of the NF2 gene is known to cause tumors of the nervous system in humans and multiple cancers in mice. Although Merlin9s role as a tumor suppressor has been well studied in other systems, its function in breast cancer is unknown. In this study, we have determined that the expression of Merlin protein is decreased in breast cancer tissues. Concomitantly, we observed increased expression of osteopontin (OPN), a malignancy-promoting protein that induces activation of Akt phosphorylation. Thus, there is an inverse correlation between the expression of Merlin and OPN in breast cancer. Ectopic restoration of Merlin in breast cancer cells significantly reduced attributes of malignant behavior as assessed in vitro by foci formation, soft agar colony formation, and invasion. In vivo, breast cancer cells stably expressing Merlin displayed reduced tumor growth and progression in athymic mice. Further, our investigations reveal that OPN-initiated activation of Akt signaling results in phosphorylation of Merlin at Serine 315 that targets it for proteasome-mediated degradation. Thus, our studies elucidate the utility of Merlin as an important biomarker in breast cancer and also identify a novel mechanism for the loss of Merlin expression in breast cancer. Moreover, our studies demonstrate the ability of Merlin to act as a tumor suppressor in breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1012. doi:10.1158/1538-7445.AM2011-1012" @default.
- W2066273583 created "2016-06-24" @default.
- W2066273583 creator A5004245304 @default.
- W2066273583 creator A5031550114 @default.
- W2066273583 creator A5041487639 @default.
- W2066273583 creator A5049662597 @default.
- W2066273583 creator A5052594464 @default.
- W2066273583 creator A5053087221 @default.
- W2066273583 creator A5057867507 @default.
- W2066273583 creator A5073266870 @default.
- W2066273583 date "2011-04-15" @default.
- W2066273583 modified "2023-09-26" @default.
- W2066273583 title "Abstract 1012: Osteopontin mediates loss of tumor suppressive activity of Merlin in breast cancer" @default.
- W2066273583 doi "https://doi.org/10.1158/1538-7445.am2011-1012" @default.
- W2066273583 hasPublicationYear "2011" @default.
- W2066273583 type Work @default.
- W2066273583 sameAs 2066273583 @default.
- W2066273583 citedByCount "0" @default.
- W2066273583 crossrefType "proceedings-article" @default.
- W2066273583 hasAuthorship W2066273583A5004245304 @default.
- W2066273583 hasAuthorship W2066273583A5031550114 @default.
- W2066273583 hasAuthorship W2066273583A5041487639 @default.
- W2066273583 hasAuthorship W2066273583A5049662597 @default.
- W2066273583 hasAuthorship W2066273583A5052594464 @default.
- W2066273583 hasAuthorship W2066273583A5053087221 @default.
- W2066273583 hasAuthorship W2066273583A5057867507 @default.
- W2066273583 hasAuthorship W2066273583A5073266870 @default.
- W2066273583 hasConcept C11960822 @default.
- W2066273583 hasConcept C121608353 @default.
- W2066273583 hasConcept C126322002 @default.
- W2066273583 hasConcept C142724271 @default.
- W2066273583 hasConcept C178628643 @default.
- W2066273583 hasConcept C179185449 @default.
- W2066273583 hasConcept C2778264664 @default.
- W2066273583 hasConcept C2778679214 @default.
- W2066273583 hasConcept C2778984943 @default.
- W2066273583 hasConcept C2779013556 @default.
- W2066273583 hasConcept C2779256057 @default.
- W2066273583 hasConcept C2780804394 @default.
- W2066273583 hasConcept C502942594 @default.
- W2066273583 hasConcept C530470458 @default.
- W2066273583 hasConcept C555283112 @default.
- W2066273583 hasConcept C71924100 @default.
- W2066273583 hasConcept C75217442 @default.
- W2066273583 hasConcept C86803240 @default.
- W2066273583 hasConcept C95444343 @default.
- W2066273583 hasConceptScore W2066273583C11960822 @default.
- W2066273583 hasConceptScore W2066273583C121608353 @default.
- W2066273583 hasConceptScore W2066273583C126322002 @default.
- W2066273583 hasConceptScore W2066273583C142724271 @default.
- W2066273583 hasConceptScore W2066273583C178628643 @default.
- W2066273583 hasConceptScore W2066273583C179185449 @default.
- W2066273583 hasConceptScore W2066273583C2778264664 @default.
- W2066273583 hasConceptScore W2066273583C2778679214 @default.
- W2066273583 hasConceptScore W2066273583C2778984943 @default.
- W2066273583 hasConceptScore W2066273583C2779013556 @default.
- W2066273583 hasConceptScore W2066273583C2779256057 @default.
- W2066273583 hasConceptScore W2066273583C2780804394 @default.
- W2066273583 hasConceptScore W2066273583C502942594 @default.
- W2066273583 hasConceptScore W2066273583C530470458 @default.
- W2066273583 hasConceptScore W2066273583C555283112 @default.
- W2066273583 hasConceptScore W2066273583C71924100 @default.
- W2066273583 hasConceptScore W2066273583C75217442 @default.
- W2066273583 hasConceptScore W2066273583C86803240 @default.
- W2066273583 hasConceptScore W2066273583C95444343 @default.
- W2066273583 hasLocation W20662735831 @default.
- W2066273583 hasOpenAccess W2066273583 @default.
- W2066273583 hasPrimaryLocation W20662735831 @default.
- W2066273583 hasRelatedWork W1509897000 @default.
- W2066273583 hasRelatedWork W1985492248 @default.
- W2066273583 hasRelatedWork W1986873250 @default.
- W2066273583 hasRelatedWork W1998310906 @default.
- W2066273583 hasRelatedWork W2014801436 @default.
- W2066273583 hasRelatedWork W2018693512 @default.
- W2066273583 hasRelatedWork W2069490142 @default.
- W2066273583 hasRelatedWork W2086492959 @default.
- W2066273583 hasRelatedWork W2096621345 @default.
- W2066273583 hasRelatedWork W2104645403 @default.
- W2066273583 hasRelatedWork W2113251343 @default.
- W2066273583 hasRelatedWork W2151584857 @default.
- W2066273583 hasRelatedWork W2294085616 @default.
- W2066273583 hasRelatedWork W2461937652 @default.
- W2066273583 hasRelatedWork W2492861142 @default.
- W2066273583 hasRelatedWork W2497026976 @default.
- W2066273583 hasRelatedWork W2894165877 @default.
- W2066273583 hasRelatedWork W2921335270 @default.
- W2066273583 hasRelatedWork W3083041480 @default.
- W2066273583 hasRelatedWork W3094014166 @default.
- W2066273583 isParatext "false" @default.
- W2066273583 isRetracted "false" @default.
- W2066273583 magId "2066273583" @default.
- W2066273583 workType "article" @default.